but it really doesn’t line up with a justifiable in-universe answer.

I went over to have a little look-see about Pon Farr on Memory Alpha.

"You only take a mate once every seven years?" "The seven-year cycle is biologically inherent in all Vulcans. At that time, the mating drive outweighs all other motivations." "And is there nothing that can disturb that cycle, Mister Spock?" "Extreme feminine beauty is always disturbing, madam." – Droxine and Spock, 2269 ("The Cloud Minders")

There's pretty much no justification for the biological reason behind the seven year cycle that I can remember. But do we know what cycle it is? Perhaps it's something to do with the planetary bodies around Vulcan? Like in humans, the menstrual cycle is about the same as one moon. (Sandi Toksvig once noted how it was definitely women who came up with the earliest calendars [in context they were talking about the "earliest man-made calendars"])

So if their planet had some sort of a cycle that every seven years there's a nice long summer because of some planetary alignment, it could be a good time for fighting and fucking.

Oh but I was just supposed to say "nice comment, thanks", and not babble on about something I was thinking about, lol.

So you’d be able to say that the Vulcan amygdala becomes hypertrophic during pon farr due to signaling by some other physical brain structure and activates the limbic system which itself becomes hypersensitive to stimulation and so on. So you can govern your pointy-eared patient some space Xanax, which increases the effectiveness of Vulcan GABA, which calms them down. Or using your advanced knowledge of physiology that no doubt extends down to the level of quantum effects, find another avenue of intervention.

Applying human neurobiology to Vulcans might not be too useful, since there are too many variables that come into play, from their telepathic abilities, to vastly different blood chemistry.

We know that at the very least, the Ponn Farr is more than just a simple neurochemical rush, at least in a way that makes it so that it isn't possible to safely suppress, or deal with via other methods. Otherwise, Voyager could have dealt with Tuvok's by giving him an epinephrine shot, rather than the somewhat complicated affair with a holodeck.

The holodeck can work, but seems to be less than 100% effective. It worked for Tuvok, but not for Vorik.

Something that also seems to work is a fight, so it is possible that a boxing match, or something like that might be effective in letting off steam enough to deal with it.

It did work for Tuvok, but not for Vorik, so not a totally effective solution.

I'm not sure that it is. Voyager likely only went with the holodeck solution because they were stranded in the delta quadrant, and no other alternatives were available.

Within the Federation, a Vulcan who felt the Ponn Farr would take leave, like Spock tried to do, or couples would try to serve on the same ship/station together to minimise issues.

Sure, but it wouldn't be the first thing. When humans became seafaring the same diffusion of mates happened. It was then exacerbated by the invention of the train. And then even further with airplanes. And in the digital age people meet each other online despite living thousands of miles away.

Becoming space faring would also exacerbate the issue, but it wouldn't be the start.