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Sleeping pills stop the brain’s system for cleaning out waste (arstechnica.com)

submitted 11 hours ago by pelespirit@sh.itjust.works to c/science@mander.xyz

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Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.

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[-] flicker@lemmy.dbzer0.com 4 points 2 hours ago

I have ADHD. Without drugs, I only sleep during the day, and sometimes, I'll skip a day and feel like crap about it no matter what I do.

I mean without drugs. I used to be an all-natural whackadoo.

Nowadays I do drugs about it and I'm allowed to be a real human. Guess my brain will clean itself when I die.

[-] Hackworth@lemmy.world 3 points 3 hours ago* (last edited 3 hours ago)

You need healthy, natural sleep. Chew some valerian root and get more exercise.

[-] some_guy@lemmy.sdf.org 4 points 4 hours ago

Eff. I require sleeping pills. I guess I can look forward to a melted brain in old age.

[-] TacoButtPlug@sh.itjust.works 1 points 2 hours ago

I wonder what melatonin does

[-] Agent641@lemmy.world 2 points 2 hours ago

Forget melatonin, I want to know wtf cheese is doing to my brain when I sleep on it.

[-] TacoButtPlug@sh.itjust.works 2 points 2 hours ago

Charlie Kelly... who taught you about Lemmy?

[-] workerONE@lemmy.world 7 points 6 hours ago

What about alcohol?

[-] Agent641@lemmy.world 3 points 2 hours ago

Fucks you up

[-] rosa666parks@lemmy.dbzer0.com 1 points 2 hours ago

Then gets you really sleepy

[-] Gullible@sh.itjust.works 43 points 11 hours ago

This has been fairly well known for at least 15 years among medi-academia. But discovering the specific pathways involved leaves me (femininely) turgid

[-] RobotToaster@mander.xyz 26 points 10 hours ago

The study was only on zolpidem. IMO it can probably be generalised to other Z drugs, and possibly benzos. Drugs that work by entirely different mechanisms like melatonin and orexin antagonists could be completely different.

[-] __nobodynowhere@lemm.ee 4 points 10 hours ago

What about Benadryl?

[-] RobotToaster@mander.xyz 4 points 8 hours ago

Unknown, but it's an anticholinergic, and those are associated with dementia.

[-] anarchrist@lemmy.dbzer0.com 11 points 11 hours ago

I wonder if ketamine has the same effect, he asked apropos of nothing...

[-] metaStatic@kbin.earth 9 points 11 hours ago

Anesthesia

yes

[-] MossyFeathers@pawb.social 7 points 10 hours ago

Actually maybe not? Iirc most "traditional" anesthesia basically knocks you down to the bare minimum of brain activity to remain alive and reliably regain consciousness (which is why being under anesthesia is usually a "blink and you miss it" ordeal, your brain isn't active enough to be aware that time has passed).

However, if I'm not mistaken, stuff like ketamine or nitrous don't do that, and sedate you in a manner more similar to natural sleep.