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Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.

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[-] TacoButtPlug@sh.itjust.works 1 points 13 minutes ago

I wonder what melatonin does

[-] Agent641@lemmy.world 1 points 10 minutes ago

Forget melatonin, I want to know wtf cheese is doing to my brain when I sleep on it.

[-] Hackworth@lemmy.world 1 points 34 minutes ago* (last edited 32 minutes ago)

You need healthy, natural sleep. Chew some valerian root and get more exercise.

[-] some_guy@lemmy.sdf.org 3 points 1 hour ago

Eff. I require sleeping pills. I guess I can look forward to a melted brain in old age.

[-] workerONE@lemmy.world 7 points 3 hours ago
[-] Agent641@lemmy.world 2 points 9 minutes ago

Fucks you up

[-] Gullible@sh.itjust.works 38 points 8 hours ago

This has been fairly well known for at least 15 years among medi-academia. But discovering the specific pathways involved leaves me (femininely) turgid

[-] RobotToaster@mander.xyz 23 points 8 hours ago

The study was only on zolpidem. IMO it can probably be generalised to other Z drugs, and possibly benzos. Drugs that work by entirely different mechanisms like melatonin and orexin antagonists could be completely different.

[-] __nobodynowhere@lemm.ee 3 points 7 hours ago
[-] RobotToaster@mander.xyz 4 points 6 hours ago

Unknown, but it's an anticholinergic, and those are associated with dementia.

[-] anarchrist@lemmy.dbzer0.com 10 points 8 hours ago

I wonder if ketamine has the same effect, he asked apropos of nothing...

[-] metaStatic@kbin.earth 9 points 8 hours ago
[-] MossyFeathers@pawb.social 7 points 7 hours ago

Actually maybe not? Iirc most "traditional" anesthesia basically knocks you down to the bare minimum of brain activity to remain alive and reliably regain consciousness (which is why being under anesthesia is usually a "blink and you miss it" ordeal, your brain isn't active enough to be aware that time has passed).

However, if I'm not mistaken, stuff like ketamine or nitrous don't do that, and sedate you in a manner more similar to natural sleep.

[-] peoplebeproblems@midwest.social 5 points 8 hours ago
[-] RvTV95XBeo@sh.itjust.works 4 points 2 hours ago

That usually helps me sleep better too

this post was submitted on 21 Jan 2025
120 points (100.0% liked)

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