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Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.

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[-] Gullible@sh.itjust.works 60 points 2 months ago

This has been fairly well known for at least 15 years among medi-academia. But discovering the specific pathways involved leaves me (femininely) turgid

[-] nooneescapesthelaw@mander.xyz 7 points 2 months ago

Obviously I understand what femininely turgid means but can you explain it just in case somebody else doesn't know?

[-] scarabic@lemmy.world 8 points 2 months ago

ie: ladyboner, the old slip n slide, juices flowing, mine honeypot overfloweth

[-] nomy@lemmy.zip 3 points 2 months ago

Like a lil cashew down there.

[-] RobotToaster@mander.xyz 39 points 2 months ago

The study was only on zolpidem. IMO it can probably be generalised to other Z drugs, and possibly benzos. Drugs that work by entirely different mechanisms like melatonin and orexin antagonists could be completely different.

[-] __nobodynowhere@lemm.ee 6 points 2 months ago
[-] RobotToaster@mander.xyz 7 points 2 months ago

Unknown, but it's an anticholinergic, and those are associated with dementia.

[-] flicker@lemmy.dbzer0.com 26 points 2 months ago

I have ADHD. Without drugs, I only sleep during the day, and sometimes, I'll skip a day and feel like crap about it no matter what I do.

I mean without drugs. I used to be an all-natural whackadoo.

Nowadays I do drugs about it and I'm allowed to be a real human. Guess my brain will clean itself when I die.

[-] pelespirit@sh.itjust.works 9 points 2 months ago

Be careful about assuming that your drugs are what they're talking about. Yours sound like they're balancing you out. They could be cleaning out your brain. Make sure to look at the study carefully.

[-] ChadMcTruth@lemmy.world 2 points 2 months ago

you probably just need fresh nutrients

[-] anarchrist@lemmy.dbzer0.com 13 points 2 months ago

I wonder if ketamine has the same effect, he asked apropos of nothing...

[-] metaStatic@kbin.earth 11 points 2 months ago
[-] MossyFeathers@pawb.social 10 points 2 months ago

Actually maybe not? Iirc most "traditional" anesthesia basically knocks you down to the bare minimum of brain activity to remain alive and reliably regain consciousness (which is why being under anesthesia is usually a "blink and you miss it" ordeal, your brain isn't active enough to be aware that time has passed).

However, if I'm not mistaken, stuff like ketamine or nitrous don't do that, and sedate you in a manner more similar to natural sleep.

[-] workerONE@lemmy.world 11 points 2 months ago
[-] Agent641@lemmy.world 6 points 2 months ago
[-] rosa666parks@lemmy.dbzer0.com 2 points 2 months ago

Then gets you really sleepy

[-] TypicalHog@lemm.ee 2 points 2 months ago

Suppresses dreams and dreams are apparently good and needed for a healthy brain.

[-] peoplebeproblems@midwest.social 7 points 2 months ago
[-] RvTV95XBeo@sh.itjust.works 7 points 2 months ago

That usually helps me sleep better too

[-] some_guy@lemmy.sdf.org 7 points 2 months ago

Eff. I require sleeping pills. I guess I can look forward to a melted brain in old age.

[-] Hackworth@lemmy.world 6 points 2 months ago* (last edited 2 months ago)

You need healthy, natural sleep. Chew some valerian root and get more exercise.

[-] TacoButtPlug@sh.itjust.works 5 points 2 months ago

I wonder what melatonin does

[-] Agent641@lemmy.world 5 points 2 months ago

Forget melatonin, I want to know wtf cheese is doing to my brain when I sleep on it.

[-] SirQuackTheDuck@lemmy.world 9 points 2 months ago

Probably just stick to the side of your head.

Have you tried eating the cheese instead?

[-] TacoButtPlug@sh.itjust.works 3 points 2 months ago

Charlie Kelly... who taught you about Lemmy?

[-] DaCrazyJamez@sh.itjust.works 2 points 2 months ago

Im pretty sure cat food and spray paint shut down m9re than just the NREM cycle in the brain...

[-] TypicalHog@lemm.ee 5 points 2 months ago

It's a natural hormone brain produces that signals to the body that it's zzz time.

[-] TacoButtPlug@sh.itjust.works 2 points 2 months ago

I love it for bedtime and it helps my autoimmune shit. Glad it's not brain bad.

[-] otp@sh.itjust.works 2 points 2 months ago

Aside from possibly becoming a dependency, I'd imagine it doesn't interfere with sleep quality. It's what builds up in your body to make you sleepy/fall asleep.

Too much might keep you groggy in the morning though.

this post was submitted on 21 Jan 2025
212 points (100.0% liked)

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