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Negative symptoms of hrt (lemmy.zip)
submitted 1 month ago* (last edited 1 month ago) by choihanna@lemmy.zip to c/mtf
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I transitioned 9 years ago and these symptoms started to me around 4 years in. Usually they're not talked about in trans spaces despite being documented.

  1. Lower body temp than people who aren't on HRT despite not feeling the cold. Sometimes I even feel hot despite my body being 36.5°C

  2. Terrible blood pressure, my nails on my fingers and toes are always purple-ish and the nails grow thin and weak.

  3. Dry skin.

  4. Extreme dry eyes, they actually cause me vision loss.

  5. Bruising, random bruises appearing on my thighs out of nowhere. One day I fell on my knees and even tho it wasn't a hard fall I got a terrible black bruise on my knee.

  6. Dizziness, people report headaches more often but I don't get those as often as dizziness.

Some people say "wow HRT made me feel so good" and I'm here feeling like a corpse in recent rigor mortis 💀

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[-] choihanna@lemmy.zip 10 points 1 month ago

I do have raynauds and they're going to run a test to check if I have Sjogren disease. They're very sceptical about Sjogren because it's a very rare disorder to develop in people with XY chromosomes but there's still that small chance.

[-] WalrusDragonOnABike@reddthat.com 7 points 1 month ago* (last edited 1 month ago)

They’re very sceptical about Sjogren because it’s a very rare disorder to develop in people with XY chromosomes but there’s still that small chance.

Do the genes involved with sperm production somehow give production against it? Or somehow related to fetal-exclusive epigenetic changes? Or is it just rare enough and transfems aren't well studied enough to know if transfems rates of Sjogren's is significantly different from cis women?

Also, if doctors go with the assumption of "AMAB, therefore we probably won't even test for Sjogren's", lots of people could just be missing diagnoses because of the incompetence of doctors to do even basic trans health care as usual.

[-] choihanna@lemmy.zip 5 points 1 month ago* (last edited 1 month ago)

They actually have done studies in trans women an they fall on the same percentage as cis men to be unlikely to develop these autoinmune diseases because it's easier to inherit them when you have two X chromosomes instead of 1. So yeah, trans women have a similar rate of Sjogren as cis men. If I end up having it it'd be a massive coïncidence

[-] WalrusDragonOnABike@reddthat.com 3 points 1 month ago

Was curious if it was just a dominant vs recessive thing and a result of mosaic expression of each X-chromosome, which could be plenty to cause autoimmune issues. Apparently the ratio for women:men is like 9:1. But if it was just dominance related, then XY's would be about half as likely to have such issues if it was just that and if it was a genetics + hormone thing, then trans women would still be just half the risk of cis women (and when they do have it, they'd typically have worse symptoms since all their cells would have the problematic gene, not just half) even if cis men rarely get it.

But I came across this: https://pmc.ncbi.nlm.nih.gov/articles/PMC9402745/

Which seems to think it may have some connection with skewed or incomplete inactivation of the non-pseudoautosomal regions which would cause excess expression of those genes, which if that was the full explanation, that would seem to suggest you need at least two X's to have problems. Given men still are apparently 10% of cases, that makes me wonder what's going on there. Is it some other problem with transcription regulation leading over production of the same genes with just one copy? Are the products just more potent or more long-lasting?

Sorry for nerding out here.

Best of luck with finding some relief from your medical challenges!

[-] choihanna@lemmy.zip 3 points 1 month ago

Idk but most trans women don't seem to get it because according to all of the trans women I talked to they act like I'm talking about something really foreign.

[-] WalrusDragonOnABike@reddthat.com 1 points 1 month ago

I think some have the thought of "this didn't happen to me, therefore this person is a transphobic concern troll" and immediately jump to dismissing their different experiences.

I think some of your wording seems to suggest that these are the normal symptoms of transitioning that almost everyone experiences and could push people to delay or avoid transition or worry about broader optics. I don't think just trying to tell you that you are wrong does anything to help with those goals though. I think compassion and understanding go further to improve image and provide useful background and demonstrates that transitioning is still worth it despite the numerous problems it can bring.

Worst case if you were trolling, I'd much rather onlookers seem a community of kind people supporting each other rather than seemly just being dismissive and rude.

[-] choihanna@lemmy.zip 1 points 1 month ago* (last edited 1 month ago)

Why are y'all so eager to jump onto conclusions. It's like you can only think on black and white, when I say these are symptoms that HRT can cause I'm not saying that YOU'LL 100% GET THEM TOO. My God in Christ, people on the internet and being so picky about wording.

Edit: Sorry if I'm being rude but my goodness, this is not the first time trans spaces on the internet are always misinterpreting what I'm saying. This doesn't happen to me irl with anyone.

this post was submitted on 10 Jun 2026
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