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please note, this much HRT at once would probably be a lethal dose
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this post was submitted on 23 Aug 2025
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I was wondering so I found a datasheet for (veterinary) progesterone. estimated LD50 of 2000mg/kg. If you weighed 75 kg (shot in the dark at some kind of "standard" body weight) you'll need to consume 150 grams of pure progesterone to reach the LD50.
I don't do injections but if you took my daily dose (100 mg) and consumed a year supply at once that would only be 35.5 grams, well below the LD50. Probably not great for you but you'll probably survive.
Estradiol has has the same oral LD50 but the injected LD50 is 300mg/kg. Assuming same body weight and an injection of 0.5 ml of 20mg/ml solution a week thats puts the LD50 at 22.5 grams and a dose of .52 grams.
I think it's fairly survivable but probably not great for you.
Doesn't overdosing cause blood clots? I feel like that would complicate the assessment since enough to cause blood clots might not be instantly lethal, but a stroke, or heart attack because of it absolutely can be lethal.
I honestly don't know if blood clots are an acute risk of your hormones are spiked that high or a chronic risk from long term high hormone levels.
I actually assumed the method it kills you would be liver failure as it struggled to return your body to homeostasis.