Yes absolutely. In a serious film that‘d be very much out of place. But also, actually serious films usually don’t have „epic“ twists and encourage cheering on the protagonist. And I can absolutely excuse an audibly sobbing seat neighbour, if the film was sufficiently impactful or laughter if I’m watching a comedy. Which all does happen. Unless either director or audience were utterly tone deaf, most movies make the audience react in a way that’s appropriate for the kind of film it is.