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submitted 1 year ago by m3t00@lemmy.world to c/science@lemmy.world

In trials

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[-] MajesticSloth@lemmy.world 169 points 1 year ago

When this was posted before someone who followed it fairly closely and others like it, updated the thread with info because the article was behind current info. They had already stopped the trials for MS because it wasn't working. So they began to just focus on one other, the Crohn's, I believe. Figuring if they got one to work, they could go back to the others and get them on the right track.

I have MS, and while this is a new approach, there have been so many articles about treatments that end up going nowhere after the first excitement. So it is still very early to get hopes up.

Hope can be a dangerous thing. Hope can drive a man insane, as Red said.

[-] kromem@lemmy.world 59 points 1 year ago

Is it possible that other person was just full of shit?

Here was an update posted on Sept 12th, 2023 from the company behind the trials regarding the MS trials:

Anokion has completed patient enrollment early in the second and final MAD cohort of its MoveS-it (Multiple Sclerosis Study of ANK-700 to Assess Safety and Immune Tolerance) clinical trial to evaluate ANK-700 for the treatment of patients with multiple sclerosis. MoveS-it is a randomized, double-blind, placebo-controlled Phase 1 study evaluating ANK-700 for the treatment of patients with relapsing remitting multiple sclerosis (RRMS). MS is a demyelinating disease of the CNS, in which the immune system attacks the myelin sheath in the brain and spinal cord. RRMS is the most common type of MS, characterized by recurring episodes of new or worsening symptoms. Anokion has designed ANK-700 to re-educate the immune system by inducing antigen-specific tolerance to myelin-based autoantigens to reduce neuroinflammation in the brain and spinal cord.

Safety data from both the SAD and MAD cohorts supports that ANK-700 is safe and well-tolerated at all dose levels tested through the dose escalation period. Further, preliminary biomarker data from the MAD cohorts displays trends in antigen-specific immune tolerance and evidence of bystander suppression to related myelin antigens, which is critical to treating complex autoimmune diseases like MS.

The study will continue with a 12-month safety follow-up expected to complete in the first half of 2024. Anokion anticipates reporting full results from its MoveS-it clinical trial in the second half of 2024.

This says that the single dose (SAD) phase 1 trial which began in 2020 was completed and they moved on to the second multiple ascending dose trial (MAD) for MS which completed enrollment and expect results in 2024. And that the preliminary data from the first MAD trial indicates therapeutic response.

And the press release talks about how they've moved on to a phase 2 trial for its use for celiacs (the initial trial use case). And then on Oct 12th they announced they will be presenting data from their phase 1 for celiacs at a conference.

A week after the announcement quoted above they released the news about their peer reviewed paper mentioning the early success in both (what likely inspired OP's article), saying:

We have now observed our approach play out in the clinic with early data from our lead programs in celiac disease and multiple sclerosis, KAN-101 and ANK-700, that demonstrated antigen-specific tolerance, bystander suppression, and an impact on disease-specific biomarkers.

None of this looks like a company that has a failing drug on their hands. And there's no indication of the MS trial being ended early - the only thing that happened early was completing enrollment early.

Being too ready to give up on hope is its own kind of insanity.

[-] evatronic@lemm.ee 34 points 1 year ago

T1 diabetes here. A cure is just 5 years away...

They told me, when I was diagnosed in 1992.

[-] Lmaydev@programming.dev 19 points 1 year ago

It always 5 years if properly funded. It's never properly funded so always 5 years.

They are testing an artificial pancreas currently. The cost is the issue as always.

[-] nul9o9@lemmy.world 13 points 1 year ago

Well damn, I got MS too but caught it fairly early. I'm hoping for a major breakthrough before it gets really bad.

[-] Lycerius@lemmy.world 7 points 1 year ago

I came for the Orange reference, but was not disappointed by Red.

[-] stoy@lemmy.zip 5 points 1 year ago

So, if I understand this right, a more accurate title would be "Research into vaccines against autoimmune diseases continues, new data indicate that a change of focus might be needed"

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[-] FrankTheHealer@lemmy.world 49 points 1 year ago

Website I've never heard of: check

Wild claims that seem too good to be true: check

Little to no proof about said claims: check

Don't get me wrong, this would be fantastic if it's true. But I'm sceptical. It feels like all those articles about a cure for cancer that then never go anywhere.

[-] where_am_i@sh.itjust.works 7 points 1 year ago

like the good ol r/science

this place is going doooown

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[-] avidamoeba@lemmy.ca 34 points 1 year ago

This sounds quite exciting and it doesn't smell like bullshit.

[-] Tylerdurdon@lemmy.world 13 points 1 year ago

Probably extremely affordable at 3 million a pop for 5 shots.

[-] partial_accumen@lemmy.world 23 points 1 year ago* (last edited 1 year ago)

Easy hack. Get a bunch of more affordable health care services during the year until you reach your out-of-pocket max, then go in and get your 3 million worth of shots all on the insurance company's dime with zero extra cost to you.

[-] plz1@lemmy.world 27 points 1 year ago

Your claim was denied, due to the insurance provider classifying this treatment as elective or cosmetic, not life saving.

[-] dylanmorgan@slrpnk.net 16 points 1 year ago

Ah, I see you’ve interacted with the American “health insurance” extortion racket.

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[-] gibmiser@lemmy.world 7 points 1 year ago

Article from September. First I'm hearing of it...

If we assume for a moment that it works as advertised - what is it that makes this a vaccine? To me it sounds like a cure or treatment.

[-] Kethal@lemmy.world 52 points 1 year ago* (last edited 1 year ago)

The creators call it an inverse vaccine. A vaccine causes the immune system to recognize a compound to attack. This treatment causes the immune system to ignore a compound it had previously recognized. So they are specifically saying it's not a vaccine (and OP is misrepresenting them), even though that word is in the phrase, something roughly like antivenom is not a venom.

Thanks for the additional clarification!

[-] winterayars@sh.itjust.works 10 points 1 year ago

It is not a cure for the reasons others in this thread have stated. It doesn't repair damage already done, it only prevents the disease from advancing. That's still a huge deal, though.

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[-] toiletobserver@lemmy.world 28 points 1 year ago

Only "ten more years to cure diabetes"

-Science 30 years ago

[-] BloodSlut@lemmy.world 6 points 1 year ago

This still wont cure diabetes, but it will prevent it from developing or advancing if you catch it early enough.

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[-] luna@lemmy.catgirl.biz 24 points 1 year ago

Oh fuck yes! I hope this works so badly (living the nightmare with crohns)

[-] Dhs92@programming.dev 8 points 1 year ago

I wonder if it also applies to ulcerative colitis...

[-] CleoTheWizard@lemmy.world 7 points 1 year ago

Same here friend. The disease is rough and hits everyone differently. Hope you’re doing alright with things tho :)

[-] Bo7a@lemmy.ca 9 points 1 year ago

I would give anything to be rid of this disease. I haven't slept a full night since 1996. And the pain... And it always seems like nobody understands. 'Oh him? He just poops a lot, ignore the doom and gloom.'

[-] NMBA@mstdn.ca 6 points 1 year ago
[-] Downcount@lemmy.world 22 points 1 year ago

In my understanding this could reverse the autoimmune reaction to Type 1 Diabetes not regrow the already killed β-cells.

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[-] ICastFist@programming.dev 20 points 1 year ago

Call me when the human trials give a positive return

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[-] Chainweasel@lemmy.world 14 points 1 year ago

Sounds pretty advanced. I bet they won't be able to activate the mind control chips until 6G cell services launch.

[-] krotti@sh.itjust.works 6 points 1 year ago

I was under the impression that we were 5G access points with the covid vaccine?

Was I lied to? I thought I was doing a service to the fellow terminally online.

[-] Xtallll 12 points 1 year ago

I wonder if a similar technique could be used to reduce organ transplant rejection.

[-] Buddahriffic@lemmy.world 5 points 1 year ago

Same but allergies.

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[-] chaosppe@lemmy.world 12 points 1 year ago

Awesome, I have an autoimmune desease that can possibly paralyse me in future. I hope progress can continue 🙏

[-] m3t00@lemmy.world 11 points 1 year ago

i like how people complain because they weren't properly spoon fed curated articles selected specifically for them by someone who gaf. 1) be kind - is a reminder to myself

[-] Maalus@lemmy.world 8 points 1 year ago

This comment isn't kind, it's obnoxious.

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[-] Jackcooper@lemmy.world 10 points 1 year ago

That's a bold claim there, dennis

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[-] Bransons404@lemmy.world 8 points 1 year ago

Is this the "T1D cure in 10 years" I was promised 21 years ago?

[-] MisterChief@lemmy.world 7 points 1 year ago

I remember seeing something on reddit about this earlier this year iirc. Definitely exciting and I certainly hope there is credence to this. Would love to see auto immune disorders go by the wayside in the next couple decades. Once they fix all the real bad ones I hope they make one for vitiligo, I'm tired of 70 spf sunblock and weird looking tans.

[-] dunz@feddit.nu 5 points 1 year ago

This looks promising, way more promising than any other cure for MS I've read about

[-] davidgro@lemmy.world 5 points 1 year ago* (last edited 1 year ago)
[-] Chuymatt@kbin.social 6 points 1 year ago

That is a different kind of immune response. It is not autoimmune, it is hyper responsive.

[-] davidgro@lemmy.world 5 points 1 year ago* (last edited 1 year ago)

Yeah, but both are "the immune system attacking something it shouldn't", so I wonder if the same mechanism can desensitize it to allergens.
The article mentioned trails for celiac which although it says is autoimmune, at least involves a foreign substance

[-] nymwit@lemm.ee 5 points 1 year ago

The article explains it as tagging your own cells in your body with a marker that makes the immune system ignore them. Doesn't seem like a foreign body encountered sporadically would work. Allergies and autoimmune (like CL IV celiac) are different classifications of hypersensitivity with different mediating mechanisms. https://en.wikipedia.org/wiki/Hypersensitivity

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this post was submitted on 20 Dec 2023
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