There's two main parts, essentially.

First is that Ctrl+Alt+Del advertises itself as a comedic webcomic, when out of the blue it decided to have a serious arc culminating in the depiction of a miscarriage. People thought it was tone deaf and tasteless, and its inclusion in what is otherwise a lighthearted work of satire conveys the wrong message.

Second is related to the author himself, Tim Buckley. Tim has a reputation for being a bit of a scumbag, and it turns out this was an adaptation of an actual event that happened with an ex of his. In the arc, the woman depicted in Loss is being neglected by her boyfriend, who is Tim's self-insert character. Loss turns her loss into his loss, and the eventual lessons learned by the characters were how she wasn't prioritizing his needs enough.

Essentially, Tim turned a real-world tragedy for one woman into his own power fantasy, and he did so through a completely left-field turn in tone for his webcomic that left readers confused. So Loss became a meme, not because of the content itself, but because people wanted it to be something permanently associated to him and his comic that he couldn't just bury or move past.

At this point it's sorta become another Rickroll, where it pops up when you least expect it. The content of the comic itself isn't what's humorous; In fact it was mocked when the original comic was released for being an unnecessary plot beat in a comedy webcomic.

https://knowyourmeme.com/memes/loss

It’s from a 2008 webcomic called ctrl-alt-del, it was bizarrely out of the normal tone.

Never understood it and don't really care to. I think it's fine, even kind of neat, for there to be this big inside joke on the internet, and it's fine for me to not be a part of it.

My only complaint is how often it seems to come up and spending time looking at something only to conclude "oh, it's just this loss thing again".

I never really got why it started. But after a while, it was funny that people kept referencing it. The commitment to the bit was what eventually made it sorta humorous.

You might enjoy this, and it should definitely clear it up: https://youtu.be/TebCHHCw9rY

I've never liked it. Joking about a woman's real miscarriage is a shitty subject to make in to a meme. The criticism of the original comic was well founded, but the meme isn't about that anymore. It would be so easy to just let the meme fade away, and I wish people would.

I was reading the comic when the strip first went up. It didn't feel tone deaf at all - I always interpreted it as "sometimes you're bumbling along in life and then reality slaps you in the face with something hard to deal with".

Apparently the internet disagrees and so we have to put up with a very boring meme.

From what I've read Tim Buckley ain't great for a number of reasons but even putting that aside my main issue is that it's dull.

I don't really get it either. I think people just like making and getting references to things for no other reason than to do it.

In addition to what other users said:

The current iteration of the meme is quite removed from the original (the comic). For a lot of people, it's about hiding a specific pattern inconspicuously, so others detect it and say "is this loss?". Like hiding a triforce in an online canvas, or reminding you of the game (you just lost it BTW).

Can you post the meme? Because I have no idea what you're taking about.

The comic it came from was supposed to be comedic, and mid-2000s comedic at that. Seeing something serious so suddenly in it was a slap to the face.

I don't find it funny but I know the history vaguely.

Never even heard of it.