Inquiry into boofing progesterone. (mastodon.triggerphra.se)

submitted 2 weeks ago* (last edited 2 weeks ago) by clocksie@mastodon.triggerphra.se to c/transgender

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Inquiry into boofing progesterone.

Is anyone else afraid to fart?

Like what if the capsule flies out? 😭

#trans #lgbtqia #hrt #lgbt

@transgender

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[-] oftheair 4 points 2 weeks ago* (last edited 2 weeks ago)

Actual suppositories don't come out from farting. Do make sure you push they up far enough and lodge them in there, water on the finger you use to put them in you can help.

They will come out from pooping though. Make sure it's an actual suppository though as they will break down and absorb quicker, other forms we wouldn't advise.

[-] dandelion 2 points 2 weeks ago

I usually lodge it high enough that this isn't an issue, but once right after putting it in, I didn't put it far enough in and I think I maybe farted and it fell out 😭 That was embarrassing to me, but it was an unusual case.

I'm most worried about it coming out after the capsule has dissolved, you can't really recover it at that point.

However, I also seem to fart more after putting it in, I suspect because pushing a finger in there disrupts things. So I would just say don't worry about it 😅

[-] RymrgandsDaughter@lemmy.world 1 points 2 weeks ago

I think I missed that memo since when were we boofing hrt?

[-] dandelion 4 points 2 weeks ago* (last edited 2 weeks ago)

not all HRT, just progesterone, and because other routes of administration don't make sense. See: Oral Progesterone Achieves Very Low Levels of Progesterone and Has Only Weak Progestogenic Effects

Abstract / TL;DR

Oral progesterone is the most widely used form of progesterone in transfeminine hormone therapy. Because of previous studies using inaccurate blood tests (immunoassays without adequate chromatographic purification), it was thought that typical therapeutic dosages of oral progesterone produced progesterone levels that reached typical luteal-phase levels in cisgender women (which range from about 7 to 22 ng/mL). However, newer studies using more accurate blood tests (immunoassays with adequate purification and mass spectrometry-based assays) have shown that 100 mg/day progesterone—with or without food—achieves very low peak progesterone levels of only about 2 to 3 ng/mL and average progesterone levels over 24 hours of only about 0.1 to 0.6 ng/mL. In accordance, oral progesterone has often shown only weak progestogenic effects in clinical studies. Higher doses of oral progesterone that might achieve better levels are limited by persistingly low progesterone levels, pronounced neurosteroid side effects caused by the first pass of progesterone through the liver, and substantial variability between individuals. While the progesterone levels with oral progesterone are apparently sufficient for endometrial protection in cisgender women, they are unlikely to be adequate for desired effects in transfeminine people. For these reasons, transfeminine people and their clinicians may wish to avoid oral progesterone if the aim is therapeutic progestogenic effects. Instead, non-oral forms of progesterone with greater bioavailability like rectal or injectable progesterone can be used. Alternatively, progestins, which are likewise fully effective progestogens, can be employed.

[-] RymrgandsDaughter@lemmy.world 2 points 2 weeks ago

interesting I don't take progesterone but it's good to know if I ever decided to.

[-] dandelion 1 points 2 weeks ago

I know everyone associates prog with breast growth, but I take it to help me sleep - 100 mg taken rectally before bed helped me sleep 10+ hours again, where before with just estrogen I struggled to sleep any longer than 8 hours. That said, I was taking large doses of estrogen for monotherapy then. I don't know what my sleep would be like on my current estrogen dose without prog.

[-] RymrgandsDaughter@lemmy.world 2 points 2 weeks ago

that's a thing? I know I typically don't sleep much at all if I don't take my bipolar meds but I didn't think it had anything to do with taking e. 🤔

[-] dandelion 2 points 2 weeks ago

Yes, I used to need to sleep 11 - 12 hours every night pre-transition, and I usually didn't feel rested even when I actually was unconscious and slept well that long.

When I started estrogen, I started sleeping 6 - 8 hours and feeling rested for the first time since I was a kid. However, I sometimes felt like I would like to have slept a little longer, and there was a feeling that the high estrogen kept me from sleeping as much.

As mentioned, taking progesterone rectally is what changed that for me, now I can sleep as long as 10 - 11 hours (usually I can't sleep 12 hours, and most of the time I can't sleep more than 10 hours).

However, I wonder since my orchi and lowering my E dose significantly what my sleep would be like without prog 🤷‍♀️

[-] RymrgandsDaughter@lemmy.world 2 points 2 weeks ago

huh, well I had to look at my medical records because I knew I had been diagnosed with insomnia about the same time as I started hrt but it was at least 8 months before I started so I don't think it would help me. especially since I don't think I'd have ever been on high dosage e since I was not mono until recently.

[-] dandelion 2 points 1 week ago* (last edited 1 week ago)

yeah, that doesn't sound related to the HRT tbh 😅 And I would say the high estrogen just made it harder to sleep in, it's not like I couldn't fall asleep or had trouble staying asleep through the night. Overall estrogen seemed to help my sleep, I felt more rested when I woke up.

[-] captainlezbian@lemmy.world 1 points 2 weeks ago

I need to ask a doctor about e with p in it

[-] dandelion 1 points 2 weeks ago* (last edited 2 weeks ago)

there is no such thing, and even if they put progesterone in something like an oil with estradiol (so it's a 2-in-1 medication like those jars with both peanut butter and jelly in a single jar, which is what I assume you're imagining), the problem is that progesterone metabolizes completely differently than estradiol.

Prog has a half-life of like 22 - 26 hours when taken intramuscularly. Estradiol valerate has a half-life of around 3.5 days when taken intramuscularly.

You wouldn't be able to inject them at the same time, they need to be taken at different frequencies.

Also, I've never heard of people getting their hands on injectable progesterone, at least in the U.S. As far as I know, it's not a common way to take the medication, while it is common to take it orally, vaginally, and rectally.

[-] cyan_mess 2 points 2 weeks ago

Only prog. First pass through the liver destroys 98% of prog if taken orally, boofing it bypasses the liver

[-] juliebean@lemm.ee 1 points 2 weeks ago

i have a counter-inquiry about boofing progesterone: why?

[-] Shaliwolf 7 points 2 weeks ago

https://transfemscience.org/articles/oral-p4-low-levels/ Basically, oral administration is way less effective

[-] nomugisan@lemmy.dbzer0.com 2 points 2 weeks ago

I don't like the whole concept of taking oral progesterone as a suppository for several reasons. I'm not a pharmacist so I won't get into it, but estrogen basically can cause insomnia and taking oral prog every night at bedtime has eliminated that problem for me.

[-] dandelion 1 points 2 weeks ago* (last edited 2 weeks ago)

taking rectal prog also fixed my estrogen-caused insomnia, and taking it orally didn't help me sleep as well as rectal administration (though I have heard the opposite from others, so I wonder if this is going to vary from person to person).

[-] dandelion 1 points 2 weeks ago

yes, oral progesterone is practically pointless

this post was submitted on 21 Mar 2025

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