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submitted 1 day ago by amia to c/diyhrt

Hi there dear blahaj.zone lemmy instance! I'm Amia, transfem. I've been since June 2025 on Estradiol Undecylate injections, 30mg/28days which seems more than enough. Progress is also pretty visible which I'm happy about and I finally got a nice sweet GP who agreed to do tests for me, nice! Now, I asked to test for my Estrogen (thus all of them and not only estradiol), Testosterone levels and also liver functions. I know that the most important part is having estradiol above 100pg/mL and testosterone below 50ng/dL but for example, with liver functions, do I need to just see if my values are just normal, or should I look into more details? Should I order more tests next time or am I being too paranoid now? I'll get those results back in a few days, so I would really like to double-check for myself how and what I am doing and maybe hear experiences and opinions from other people about all this. Thanks in advance! *PS: First of all, I know that I can just look up the needed values online but I just want to ask for advice to make sure I'm not missing out on anything. *

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[-] dandelion 1 points 1 day ago

liver function is not particularly relevant if you're doing injections and aren't taking any anti-androgens like bicalutamide that impact the liver (AFAIK, I'm not a doctor), but you're just looking for normal levels, yes. (For what it's worth I saw a change in my liver enzymes when I took bica, and I ultimately stopped taking it because it wasn't helping my biochemical dysphoria because it doesn't impact the central nervous system much.)

You seem to have the right impression - lots of doctors want E blood levels of 100 - 200 pg / mL, and yeah <50 ng / dL for T sounds about right.

You're mostly looking for estradiol blood test, I don't remember a bunch of tests related to that, just the one. I think an endo I had tested for Sex Hormone Binding Globulin and Free Testosterone separate from just normal T levels, as well as Albumin. He said the SHBG helps interpret the hormone levels ๐Ÿคทโ€โ™€๏ธ

[-] Domi 2 points 16 hours ago* (last edited 16 hours ago)

Hey Dandelion, can I ask you about your Bica experience?

Sorry for the sensitive question, feel completely free to say "pass" or just ignore if you'd rather not answer. Also DM if you'd prefer to answer privately.

Bica is supposed to preserve erectile function better than other anti androgen, which obviously isn't always desirable but I kindof want that for me. Was that your experience?

[-] dandelion 1 points 13 hours ago* (last edited 9 hours ago)

I'm very open and happy to answer questions like this publicly, but thank you for your sensitivity ๐Ÿ˜Š

I took 50 mg of bica once a day for two months at the very beginning of when I started E.

During that time my E dose fluctuated a lot, but I was injecting estradiol valerate in oil subcutaneously, averaging a little more than 5 mg / week total (I think a lot of that time I was taking ~2.5 mg twice a week).

When I quit bica, I increased my dose to 5 mg every 4 days or so, but kept tweaking my dose chasing more efficient and reliable T suppression. (Usually a day or two after trough I would have physiological signs of T with corresponding mental health symptoms like anhedonia, depression, anxiety, parasomnias.)

For context, when I first started HRT I was pretty neutral about my genitals and thought I had no dysphoria, but once I socially transitioned and started E, my experiences shifted (I think I had suppressed feelings from before, e.g. I experienced dissociation commonly during sex but always understood it as something other than dysphoria - now I understand it was probably caused by gender dysphoria, as a vaginoplasty has significantly improved my dissociation and other symptoms during sex).

So, almost from the start, I had it as a goal to maximize penile atrophy, and I had little interest in erections (and later esp. an active dislike and distress from erections).

All that said, I suspect the combination of bica and estrogen will absolutely risk penile atrophy, and I definitely experienced atrophy on bica + E.

Atrophy is what impacts the ability for the phallus to be erect, and in particular the spongey material to hold blood and stay hard enough for penetration. What happens is that the spongey material is a "use it or lose it" situation, and testosterone dominance causes the phallus to become erect while you are sleeping ("morning wood" is just a form of what is formally called nocturnal penile tumescence - a fancy way of saying a night time erection).

Those erections maintain the ability of the spongey material to hold blood in the future, and without involuntary night-time erections, there is a loss of that function (it can't hold as much blood, etc.).

Your mileage may vary, as is usual with HRT, but my experience with penile atrophy was that after I started HRT, I stopped having those involuntary erections when I was sleeping (mostly) and I noticed when my penis became erect, it just wasn't as "hard" as it could be before. This was maybe a bit like when you're not fully aroused when first forming an erection, but instead you couldn't get any more erect. In terms of penetration, this made it harder to feel safe when penetrating, because a semi-hard penis can sorta bend. That said, I was able to generally make it work and penetration was possible if not as safe or easy as before when the penis could get harder - but I also formed a preference for not penetrating over time, so eventually that just wasn't so relevant and I just stopped using my phallus for penetration and started treating it more like a clit (e.g. I liked to tuck it into underwear so I couldn't see it and so it would be held to my body, and then using a vibrator on it through the underwear - that helped with of the distress I increasingly felt).

I actively wanted to cultivate penile atrophy, but in the end I wasn't able to prevent erections, and my erections remained semi-hard (maybe like 70% of the original?) and still technically capable of penetration even to the end.

I occasionally would get involuntary erections, but it became a rare occurrence, and it usually bothered me significantly when they happened.

If you want to maintain function, the advice I've heard is: give yourself fully hard erections on a schedule, I would personally aim for once or twice a day to be conservative simply to replace those erections you would have had overnight. You might want to make sure the erections last long enough. I don't think orgasm is important or anything, it's just about getting the penis as hard as possible and staying that way for a bit. If you read that wikipedia article on involuntary night-time erections, it looks like the average number of erections is around 5 - 6, and the average duration of the erection is 15 - 30 minutes. You could use this to form a basis of a schedule, if you wanted - maybe try 2 erections a day maintained for 30 minutes (set a timer, use reminders and / or keep a log to track).

Another common suggestion is to rub testosterone gel / cream into the phallus and testes to help maintain their function - but whether you can tolerate the added T dose is dependent on how sensitive you are to biochemical dysphoria (I suspect T cream would have given me worse mental health symptoms, for example - I didn't ever achieve consistent freedom from those symptoms until I had my orch, fwiw).

I suspect the T cream on the testes is how trans pornstars are able to keep functioning ejaculation, etc., though it's also possible they just don't take anti-androgens and they maintain feminization through surgeries or lower dose E without T suppression? Honestly it's unclear, and I know a girl IRL who reported T-cream did not succeed in maintaining her male-style ejaculations. (Obviously you still produce ejaculate on E, it just won't be like a man's semen, it's like a clear fluid - more akin to female ejaculate.)

Hope this helps, let me know if you have any questions!

[-] Domi 2 points 10 hours ago

Hey girl, thank you so much for the detailed reply. I'll give it a full read tomorrow when I'm not slightly drunk. <3.

this post was submitted on 26 Feb 2026
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