I really dislike being set back far when I die or mess up. I can handle a fair bit of repetition, but replaying the exact same thing over and over because I died is frustrating and boring.

Which means that I particularly dislike when games have lousy checkpointing or save systems. I also dislike when games are too difficult and I can't turn the difficulty down to at least get past whatever is giving me a hard time. And of course, unskippable cut scenes right after a checkpoint are a classic pain in the ass.

Examples:

1. I just finished Outer Wilds and found that game's checkpointing to be pretty frustrating. So many boring trips to Brittle Hollow because I lost my footing. I almost gave up because it was so bad.
2. I never finished GTA 4. I got stuck in some mission where there was like a 5 minute drive and then some difficult combat. I kept dying and having to redo the very boring drive over and over killed my motivation. I don't even know why it was so hard. I played GTA 5 twice with no issues.
3. I tried Dark Souls once. Lol, lasted maybe an hour before giving up. Now I'm very wary of any game that doesn't have configurable difficulty levels. Thankfully, most games these days are actually progressing to more granular or meaningful difficulty levels.