Given that heat-induced deamination producing dU in isolated DNA continues to proceed over extended times (Figure 2b), (18) hours of roasting or smoking could potentially result in higher levels of damage, although this was not tested here. For dU in briefly roasted beef, the amounts found here correspond to milligram quantities in a serving of cooked meat, as much as 1000 times greater than concentrations of HCA or PAH molecules in cooked meats

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