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hey! been on e for a couple weeks now, but I haven't really felt anything :/ (self.mtf)
submitted 3 weeks ago by tunasyne to c/mtf
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been taking estradiol enanthate via subq injection for the past 3 weeks, 0.15 ml every 7 days. i haven't really felt anything different tho... is it too soon to tell? im not on t blockers, mainly bc im still closeted, but i thought by now id feel some change by now

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[-] dandelion 12 points 3 weeks ago* (last edited 3 weeks ago)

DIY enanthate vials usually have 40 mg / mL, so 0.15 mL should be 6 mg?

Using the injectable estradiol simulator, this is what levels would be estimated to be over time:

Notice how it takes nearly a month to even get to a steady state ... EEn has a half-life of 5 - 7 days, so it takes a week to peak and another week to eliminate. This is compared to estradiol valerate (EV) which has a half-life of 3.5 days, so EV peaks faster and higher, and eliminates much faster than EEn.

When I first started EV injections, I could feel changes the night I injected, but I didn't feel any obvious benefit or mood change until the third day or so.

But it's important to note that not all trans women react to estrogen the same. Some feel no difference at all. Others actually have worsened dysphoria.

So early on you are not likely to notice many physiological changes. In my first month or so of HRT, the earliest changes I noticed were softening skin, changes to body odor (less spicy / less smelly), and fewer involuntary erections overnight and in the morning when I wake up. I wonder if you will start noticing these soon, too.

EDIT: I had sore breasts pretty quickly, too - I think it was a matter of weeks, but I was taking EV which brought my E levels up quickly. I would expect breast soreness in 1 - 3 months with EEn, but I'm not certain - I bet others have written about their experiences starting with EEn.

[-] tunasyne 4 points 3 weeks ago

thank you for that graphic! i hope so too actually.

this post was submitted on 01 Apr 2025
55 points (100.0% liked)

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