In a mouse model. The mice don't have alzheimers they have... something we gave them that looks like it... Hopefully it is similar enough
We did something to the mice then rescued it in a different way. Hooray! Next we'll save test tubes from cancer...again.
If you can’t get excited by incremental advancements, you should probably unsubscribe from science as a topic.
Dude it's worse than that. I was a working neuroscientist for almost twenty years. So...jaded.
This is why almost everyone does development, not research.
I feel like if the average person had any remote idea just how gloriously, horrifyingly complicated the human body is, we would be simultaneously far more skeptical of press releases, and far, far more invested in the actual science going on to figure out how to keep the whole cathedral from collapsing.
There has been a fucking epidemic of MD/scientists running to the media with miracle cures lately.
Mice do not get Alzheimers, they were engineered to show one aspect of the disease that has been promoted by fraudulent studies. As for the reversal, mouse brains are highly plastic and similar to a human baby, nothing like a >60 year old.
Well I hear we are adding more plastic to the brain through micro dosing micro plastics in our every day lives. Wait...
HAH HEY EVERYONE THIS GUY THINKS MICE HAVE BRAINS MADE OF PLASTIC /s
Yeah, I didn't read the whole thing but apparently only in 5xFAD mice. I wish they would have also tried it in a Tau model like PS19.
Both pointless. Mice do not get neuronal loss like human disease. These diseases have been stalled for 30 years on animal models generating "high impact" manuscripts that go nowhere.
Meanwhile, in human research, just taking vaccines can lower AD incidence by 30%. For real, proven. Not "soon", not "within 5 years" . That is far mor relevant than animal model studies.
An unforgettable moment for those mice
Underrated comment.
Mouse grandpa: John?
Mouse Grandson: Grampa, you remember me?
Mouse grandpa: Yes, I remember. It's all coming back now. You ate my cheese and fucked my wife you piece of shit!
Sounds of mouse battle reverberating
On the one hand, I really really want it to be a world-changing breakthrough for real this time. I've been losing my dad to Alzheimer's for several years now and even if it's too late for him I would just hope that nobody else has to go through that in the future. On the other hand, knowing that it's someone's business model to jerk at my hope and heart-strings for ad engagement has me more or less ready to fire futurism into the fucking sun
Odds are it is at least somewhat bullshit, oversold, to garner more funding.
Oh, yeah? How come they still cant tell us how fucking magnets work?
Eat shit, "science."
I believe this population of super-mice we are making that are immune to all disease will be the dominant life form on earth after we have extincted ourselves. Im in favor of this future.
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Where is that comic about reporters creating misinformed headlines about science?
Scientific advancements often seem like the only good news we ever seem to get.
Any drug would cost 20 million a course. Not even exagerating there either. A new one is doing dynamic pricing, charging some as much as 3 million and others over 1 million for a course. For drugs developed with goddamned charity money.
Now we work towards changing elderly people into mice to cure their Alzheimer’s!
Let's see if it works for Charlie now.
Unfortunately, mice don't get Alzheimer's disease. This has been a claim for a while in animal models. I'm sure it's good scientific work, but the press release is making wild claims.
it's lab mice. it's NAD+. i can't remember because i'm not an ad researcher, but there are 3 models of AD. one is NAD+, two aren't. Most of the research was going into NAD+ or another, and they discovered that that specific model was not going to help human patients. It did nothing to effect research or funding. that was about... 15 years ago? so forgive me if i don't get up.
Not until after the orange man is gone. Please.
With all the things we have learned from mice physiology, we could make them super-mice that had supreme physique, intelligence and lived well for a hundred years - move over AGI, the mice overlords are here...
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dart board;; science bs
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