This is a pretty big deal and should be patched, but it's not the worst case scenario. The worst case scenario would be if an attacker could do this remotely through your game.
Basically, if someone has the ability to change the shortcut on an end machine to specify additional arguments, your game could be used to run malicious code on that machine under the guise of your game, making detection harder.
The benefit is that modifying a shortcut is not an easy thing to do without tricking the user, or using an already established remote control of the endpoint.
However, this is still a vulnerability and one that should have a minimal impact if it were patched. You should install this patch if you make games with Unity.