RNACap uses pH-sensitive coatings and pressure-triggered release membranes to remain intact in the stomach. Contents are released in the intestine in response to neutral pH and peristalsis.
Nanoparticles were formulated using G0-C14, PLGA, and PEG-lipid components for mucus penetration and endosomal escape. A 5% DMPE-PEG formulation showed optimal transfection in vitro.
oh man. as a needlephobe. please. please. please.
I just saw a similar article about using this delivery method for insulin. I’m just some plebeian but it’s all very interesting!
Thanks for the summary!
no prob. If I read the article I usually try to paste what I feel is the most relevant bit and once in awhile I will do the whole thing or if its too long I will add a comment encouraging people to read the article if its good enough.
General discussions about "science" itself
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