I feel like this misrepresents the chaos gods, except maybe Tzeentch.

Khorne: Drown your depression in HATE!

Nurgle: That's just how some people are, you'll learn to live with it. (Unstated, "Because I'll give you no choice.")

Slaanesh: What you need, is a distraction. We have sex, food, drugs, or art.

How can the emperor be so smart, brilliant, etc… and so obviously terrible in all the soft skills needed to actually enact all his genius plans?

OP this is clearly some heresy. The Emperor ask his fellow men to rise above their base desires and embrace the highest virtues, while the gods of chaos only seek to bring you to down to their level.

This is heresy. Stop this chaos propaganda and repent.

I didn't know you degenerates had anime wifu chaos gods too.

I'm of the thought that Slaanesh would encourage you to indulge and dive deep into your depression. You'd begin to find comfort in avoiding anything that worsens the accompanying anxiety until one day you find something that lets you avoid it all and even feels good in ever increasing excess. Eventually all that matters is your quest to get more of that something leaving behind a wake of chaos as you leave your job and destroy your family, community, and yourself.

"Just man up" doesn't work in the long run at all. You will die to a heretic before you realize it though.

Not Big E the wrestler I presume?