For me, the last "ah yes, the future" moment was going from "broadband" to seeing real fiber at a friend's house that was 100x faster. Insanity at the time :)
mRNA vaccines do it for me at the moment.
https://www.genome.gov/about-genomics/fact-sheets/Understanding-COVID-19-mRNA-Vaccines
All the more reason to despise RFKjr.
Montana is banning those. Expect a nationwide ban to come soon.
I recall having vaccines in the 80s, probably what saved me from polio
The commenter said mRNA vaccines.
I agree, they most certainly did say mRNA
Are you familiar with the differences between traditional vaccines and mRNA vaccines in terms of production?
If the innovation is the airplane then it doesn't matter if it's an old timey biplane or or a next generation stealth fighter
If the the innovation is the vaccine then it doesn't matter if it's a smallpox vaccine or an mRNA vaccine
But that's an arbitrary distinction. You could also argue, "what's the difference between a vaccine and medicine?" Or "what's the difference between medicine and physical medical treatment?" mRNA vaccines involve more innovation and impact than bloodletting via leeches.
But I won't respond to that line of thought anymore because you didn't answer my question.
You can choose to answer my question or just not reply. Do you know what the differences are between traditional vaccines and mRNA vaccines?
I kinda thought using the first vaccine and the most current vaccine in my explanation would infer that I am aware of the difference
The question is meant to be more conceptually overarching and abstract
I'm not the original poster, but I'd like to say I don't know but am now curious to know what's the difference and what makes it more innovative
I'll start by saying I'm not a doctor. This is my layman's understanding.
Historically, vaccines have been samples of either weakened or dead viruses. Through trial and error, we've been able to determine how to weaken or kill these viruses, then inject them into ourselves in the hopes that our immune system can learn to recognize and kill the virus. This has worked really well for a long time, but it's costly and can be difficult to scale. For example, horses have very strong immune systems. It's quite common to inject a virus that hurts humans into a horse, then harvest the horse's blood to acquire the material needed to produce a vaccine. The horse's immune system learns how to kill the virus, and we can use the to teach our immune systems.
mRNA vaccines take a whole different approach. They kind of co-opt the mechanism that viruses use to replicate.
First, let's tall about what RNA is. You might know that DNA is used to produce proteins, and proteins are the tools that life uses to do... stuff. Almost everything, really. Thing is, DNA is stored safely inside cells' nuclei, but protein production happens outside the nuclei, in ribosomes. So if DNA is needed to produce proteins, but DNA can't be moved to the protein production center, how do? Our cells can produce another molecule called RNA. It's basically half of DNA. Since you can derive one half of DNA from the other, it essentially carries the same information. Inside the nuclei, RNA is produced based on your DNA. That RNA is then moved to the protein production center to be used as the blueprint for protein production. Voila! Your cells have proteins now and can do stuff.
What did that have to do with viruses? But first, how do viruses work? Funny thing: at their core, viruses are kind of like protein missiles with an RNA payload. (This is why people argue that viruses aren't really alive.) Viruses pierce your cells and inject their RNA into your cells. That RNA provides the blueprints to produce more RNA and the protein module, effectively, a copy of the virus. The viruses uses your cells' infrastructure to reproduce.
With me so far? Here's where it gets cool.
What if we could capture a virus' RNA? What if we could then isolate just enough of the RNA blueprint to get some part of the protein missile, without the payload? And then what if we could get so specific that we could make sure that part of the protein missile is something your immune system could learn to recognize and kill? Lastly, what if we could package this harmless but recognizable part of the virus in a manner that your cells could mass manufacture it?
This is mRNA, the "m" standing for "messenger." mRNA vaccines basically give your cells the blueprint to produce a recognizable part of a virus that won't hurt you. Your cells then produce that virus part, and your immune system learns how to recognize and kill the virus based on that part.
The best part? We can do this fast. No need for trial and error on how to weaken viruses. No need to manage livestock like horses specifically to harvest their immune system material. The COVID vaccine was an mRNA vaccine. I haven't actually checked the numbers, but I'm very confident that the COVID vaccine R&D was the fastest humanity has ever had for any vaccine. We'd been researching and experimenting with mRNA vaccines already, but they weren't yet approved for medical use. For good reason, medicines go through a huge amount of testing before we start injecting ourselves with magic feel-good juice. Given the emergency that COVID was, most countries fast-tracked their approval process for the COVID mRNA vaccine. In the long run, this may actually have been a benefit, as we've learned a lot about how to produce these types of vaccines rapidly, at scale and even update them for new variants of a virus.
So yeah, mRNA vaccines are super fucking cool. They're also a remarkably clever innovation, copying an idea from viruses and adapting it to a way to kill viruses. Theoretically, future vaccines should be produced faster, be better targeted, and have fewer side effects.
Thanks for coming to my TED talk? 😅
Every so often I hold a microsd card and I think about how much storage is on that pinky-nailed sized $20 device. Compared to ancient hard drives it is one of the few things that makes me remember "oh shit I live in the future".
Couldn't agree more. I put a 128GB card into my action camera last night, then remembered that my first computer had a 170MB hard drive. That's close to a thousand times more storage, and according to t'internet, it's physically more than two thousand times smaller :o
The first hard drive I used was a whooping 5megs and the CP/M machine couldn't handle it so it was partitioned as a million floppies.
I have a 512GB card in my steam deck, seen listings for them upwards of 2 TB, reliability scares me a bit with that much data but still, it's impressive how far flash memory has come. I remember being excited about a 64MB thumbdrive and buying my first 1GB one.
If you remember navigating with a compass and map, GPS is goddamned magical.
The internet has totally changed how humanity works, learns, socialises, and plays. I cannot think of a more dramatic social upheaval, aside from possibly the industrial revolution, or the taming of the horse.
The first information revolution, is somewhat equivalent. With the invention of the printing press, distribution of information became an order of magnitude cheaper.
Literal months of work to produce a single copy, became a few hours to setup the movable type, then produce as many copies as you want.
Daily gazettes became a thing that was possible to do.
I agree. I suspect the internet will retrospectively eventually even be looked at as an "information revolution" on par with the industrial one. I know that sounds like an enormous claim but there is a long road yet, so I don't think it will turn out to sound so crazy. Each revolution (and its increase in power) comes along with responsibilities and potential dark sides, though. I think similarly to how the industrial revolution opened the door to industrial war, we are already seeing the pain brought by various (distributed, automated) information war techniques. I love how we live in an age now where a person with internet access and enough tenacity can eventually learn almost anything, and contribute back, but at the same time I worry deeply about the rolling waves of belligerence, disinformation & selective amnesia coercion, gatekeeping, and fraud that have come with it. I hope humanity can get those under some degree of control soon.
Honestly if you're not putting the internet and the general proliferation of personal computers and then smartphones in the "truly innovative" category, then I'm not sure anything will make the cut—I'd make the argument that both are more innovative than flight which is something we can observe in nature.
When phones got developed so much, you can virtually do half of the things on them as you would a laptop.
It sounded like you didn't see what the point things were when they arrived around your time. But I can tell you, the passing 90s and 2000s just straight shot technology faster than we can comprehend.
I'm a software guy, so I'm gonna go with 'free compilers.' Back when every company was keeping their secret sauce close to their chest, RMS turned around and released gcc for free. That was... new, to say the least. It paved the way for much of the software you see eating the world today.
After reading the comments here, I see the problem: You judge past things by what they have become, and new things by what they are. Nothing will ever be "truly innovative" by those standards.
The automobile was for a long time just a more expensive carriage. The airplane was a pass time for the ultra rich, while anyone else got by with hot air balloons if they wanted to fly. The soviets got to space first by pointing a ballistic missile upwards.
We have CRISPR and can alter the Genes of any living organism to match our needs, but oh well, it's only used by labs right now and anyone else got by perfectly fine by selective breeding, can't call that innovative, can we?
... The automobile was for a long time just a more expensive carriage...
100%. To add:
Automobile was actually slower than the horse for good many decades.
A good horse is like 3 horsepower at least :)
The Internet has changed almost every aspect of daily life, I don't see why you don't think it is as innovative as the invention of the car.
Accurate and repeatable motion systems.
Born too late to say that semiconductors are the thing for me, but the use has made closed loop control systems viable. Along with stepper, servo, and now new to me piezoelectric motors and linear stages.
If you think that the internet is not revolutionary, what right do you have to claim that automobile ever was?
As unpopular as this may be, LLMs (aka. "AI" like ChatGPT).
I don't think we've seen something that'll change the world as much as I think it will since the Internet was introduced. It will change the way we interact with computers. For a lot of people, it already has.
Don't use them tꝏ often , specially not enough to know how gꝏd they truly are . But if want basic info about some thing , don't like sifting thru pages and pages of search engine garbage . LLMs I used automate that process and consolidate the info into something fairly easy to understand
Peops hate LLMs bcus they supposedly "turn peops brain to mush" , but … what if my brain's ALREADY mush ? Think this's one instance LLMs might help more than hinder , so shouldn't be discarded entirely
Well, I disagree with the premise.
But perhaps one of the more obvious physical examples are Blue and White LEDs (1992). Small gadgets used to always have red LEDs, maybe green ones, or an unlit 7 segment display, everything else was too expensive or too energy consuming for battery powered devices. And not only that, RGB Diodes also saw the end of pretty much all cathode-ray tubes.
You see kids, back in the olden days before white LEDs, the only way to get blue light was to throw high energy electron ray on a phosphor coating. So anything blue or white before the 90s was made with that technology, from car radios to TV screens.
I'd personally also keep an eye out what the cheap electric motor will do next. From "hoverboards", civilian drones, e-scooters and the modern e-bike, it's only a matter of time before the new use case will emerge.
Gene Editting with CRISPR and other techniques. Eventually this will be truly personalized medicine at an affordable fee.
Fusion with more power output than input will become a game changer. Currently we have done fusion but the energy to do the demonstration was in total more than the output
Katamari Damacy
Naaa.
Na na na na na na na, na naa naa na na na
Life is vastly different than in the 80s. You can literally know anything you want right now, simply by asking an artificially intelligent handheld computer that has access to every discovery known to man. We're on the cusp of being able to cure almost any disease and live forever. We can blow the planet up 10x over and still have ammo left. Scientists can see so far away that they can almost see the beginning of time. Nothing your great grandfather saw in his life will compare to what you will see in yours, have already seen.
"Um, yeah, but we could have already known everything thousands of years ago if we had just made any effort. AI is just a worse version of what evolution already made between my ears. We could have already blown the planet up 70 years ago. The beginning of time is sooooo 13.8 billion years ago, YAWN!" - OP probably
I’d say the iPhone. A truly innovative, smart phone. When it first came out, I mean.
3d printer
dick sucking robot
I'm a mechanical eng turned software, computing and the like are super visible but there's been a huge amount of advancement in physical things in our lifetime, Steel in particular. By no means an expert, some of this I've been out of the industry for a while so just operating on memory, totally welcome any corrections!
I'm not a metallurgist, but worked with them, there's lots of grades out there but some of the stuff being used in automotive is seriously interesting (I think they're boron grades but I can't recall), needs specific treatment like hot stamping but they can easily hit into the 1-2 GPa range for yield strength once it's processed. It's allowed material to be rolled thinner for the same part strength so you end up with lighter vehicles.
Coatings too have changed a lot, non-chromium passivation is a thing, galvanised materials are no longer just zinc + a bit of aluminum, there's aluminum + silicon coatings that are supposed to offer decent corrosion resistance at high temperatures, those fancy automotive steels get coated in it for things like mufflers. Construction there were zinc+magnesium coatings starting to show up, supposed to be resistant to coating damage.
Processing has changed a lot in a century too, steel is substantially metallurgically cleaner these days, probably actually cleaner too with more electric arc furnaces and hydrogen direct reduced iron.
It's oldish these days but pipeline inspection was increasingly using Electromagnetic Acoustic Transducer (EMAT) tools when I worked in that field. It let you do ultrasound inspection of steel pipes without needing a liquid medium, so things like cracks and material defects that are hard (or nearly impossible) to find using Magnetic Flux Leakage tools are a lot more accessible to gas pipeline operators as they don't need to do things like plan around liquid batching.
The first time I tried steering-assist on a car felt like a significant transition.
Even though it was a simple "stay in lane"feature, feeling the car moving the wheel took a bit of getting used to.
I know that there are lots of other replies about the Internet and phones, but I've always liked maps so as a specific example that's an area that has transformed astoundingly. I have a map in my pocket that can show me anywhere in the world, give me directions, monitor traffic levels, show aerial photographs and street-level photographs of many areas of the world. I can fly around a 3D view of a city's buildings, and even see where my family members are.
Oh, and you can buy vacuum cleaners that don't need bags, now.
Bone conducting headphones
Peltier personal AC neck coolers. (eg Coolify2)
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