I don't know about the hub specifically, but I have a One Touch portable external HDD that touts some of the same features. I've never had any particular problems with it - it's just a normal USB mass storage device. The "special features" provided by the Seagate Toolkit (not available on Linux) seem like they're done at the filesystem level.

If you don't care about encryption, it will most likely just work - format it however you like. If you care about encryption, there's ways like LUKS or filesystems with FS-level support, depending on how much you care about interoperability with non-Linux systems. You might also be able to do something kooky like format it with Bitlocker on Windows, which I think can still be mounted on a Linux system; I was able to access my encrypted Windows partition from my Linux install on my Surface if I entered the key - I'm sure there's a way to automate that part.

Rather than play the "will this product work on Linux" game I bought an enclosure and made my own. I got an Orico enclosure and put a large HDD into it.

Most enclosures are OS agnostic (but check anyway) and you can put quite large drives in them.

I have one and it works as a drive but all the seagate software doesn’t run in Linux.

I dunno if the Hub software works but I do have a Seagate OneTouch portable 4TB drive and it worked without issues on Linux after reformatting like I would any other drive.

Maybe?

It depends on if the added functions are software-based, or if there's some hardware funkery going on.

Given it's a consumer product, I'd wager it's just a drive in an enclosure that does all their mirroring/backups/encryption stuff in software, but their marketing material doesn't seem to say one way or the other.

Google indicates older versions can be reformatted, so I'd bet that's still true.

If I'm wrong it's not my fault, etc.