Connect has instance and community blocks.

As suggested, Connect. Excellent filter capabilities. My feed is pretty enjoyable now, at least on my phone. The only thing I'm missing is filtering out comments with specific keywords but that isn't a huge issue. I downvote and occasionally block a user if they just post an emoji or a pun.

I even have a "system":

• Instances with annoying users like those on hexbear, blahaj or lemmygrad: complete instance block.
• Communities which I have no interest in: block
• Spam bots reposting articles, reddit threads or links to some random blog post: instance/user block depending on context and how many posts per hour they spit out.
• Too many posts about the same subject that I don't care about: keyword block. Absolute bliss when Elon Musk and Donald Trump is gone.

I only interact with content that I find interesting. Not a huge fan of defederation if it's not pedo paradise or spam bot/troll farm. There are some good tutorials online on how to tie a noose if one of those two are your thing. Everyone has the right to an opinion and I have the right to ignore crazies.

Connect will block instances or communities. Several instances like .world have defederated hexbear at this point (as everyone should), so that's an option too.

Sync has it but not for comments I believe.

I was able to block posts from hexbear on Sync but I still see comments from users in posts from other instances.