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Results: In the fully adjusted model, significant positive associations between P_CARB and CVD risk were observed in the pooled analysis, showing that the HRs (95% CIs) for CVD across increasing quartiles of P_CARB were 1.00 (reference), 1.16 (0.94-1.44), 1.25 (0.96-1.63), and 1.48 (1.08-2.03). The restricted cubic spline regression analysis confirmed a linear dose-response relationship between P_CARB and CVD risk in both cohort studies, with all p-values for nonlinearity >0.05.

Conclusion: Our findings suggest that a carbohydrate-based diet high in proportion to total energy intake may increase the risk of CVD among middle-aged Korean adults, underscoring the importance of balanced macronutrient distribution. However, more research is needed to evaluate the sources and quality of carbohydrates in relation to CVD risk in this population.

Full Paper: https://doi.org/10.1016/j.clnu.2023.06.013

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[-] TootSweet@lemmy.world 3 points 1 day ago

Saturated fat causes heart disease. Unsaturated fat causes inflammation. Trans fats are basically poison. Protein is bad for your kidneys. Carbs cause cardiovascular disease. Glucose causes diabetes. Fructose is bad for your liver. Alcohol will fuck your liver over but good. Not eating calories at all will make you starve to death.

[-] jet@hackertalks.com 3 points 1 day ago* (last edited 1 day ago)
  • Saturated fat causes heart disease.

Could you show me the non-epidemiological proof of this? If not possible, epidemiology with significant risk ratios, or absolute risk illustrated? In the epidemiology did they control for carbohydrates and sugar (no). The reading I've done indicates this is not the case

  • Unsaturated fat causes inflammation.

What is the mechanism here? Seed oils do cause inflammation due to the interference with cholesterol sites.

  • Trans fats are basically poison.

Sure, agree

  • Protein is bad for your kidneys.

Could you show me the proof of this please? My reading is the opposite.

  • Carbs cause cardiovascular disease.

Yes, absolutely.

  • Glucose causes diabetes.

The key here is carbs are just glucose, so they are the root of metabolic problems. You can't have diabetes without carbs, and without the carbs you wont develop CVD.

  • Fructose is bad for your liver.

Strong agree

  • Alcohol will fuck your liver over but good.

Yup, We have the double whammy of NAFLD and AFLD swapping in frequency, due to all the carbs and gluclose.

  • Not eating calories at all will make you starve to death.

Agreed, so someone needs to eat a food low in carbohydrates, glucose, alcohol, fructose... I would strongly encourage people to eat a diet rich in protein and saturated fat, but any whole food eating pattern would be better then the current state of affairs.

[-] TootSweet@lemmy.world 2 points 14 hours ago

Mostly what I meant was more that every kind of calorie source is vilified by someone who imagines themselves an authority. I probably should have put each of those sentences in quotes or something make it clear I wasn't stating them as fact, but just as the sort of thing that people say. But, to talk about where I've heard these things mentioned:

  • Yeah, I know there are a lot of objections to the claim that saturated fat causes heart disease. I don't really avoid saturated fat myself.
  • The bit about unsaturated fats, I was being a little bit imprecise conflating PUFAs with MUFAs while also leaving out any free radical involvement and arterial plaque. But I'm sure I've heard random folks on, say, Robb Wolf's podcast (a long time ago) advocating for avoiding PUFAs in favor of saturated fats based PUFAs being more susceptible to oxidization by free radicals. (Not saying that source was a particularly good or bad one. Just driving home the point that there's no calorie source you won't find vilified by someone.)
  • Trans fats being poison isn't even controversial now-a-days. Heh.
  • With the protein and kidneys thing, I'm referring to "The China Study". My understanding is that its results were taken by some to indicate protein could cause kidney problems. Also, my grandmother's nephrologist had my grandmother limiting her protein. (And, of course, there's also a big difference between the claim that high protein causes kidney problems vs the claim that high protein can exacerbate existing kidney problems. But yeah. Also, I don't put enough stock in those claims to try to limit my protein intake.)
  • About carbs, there are definitely organizations that at least at one time advocated for high-carb diets. And you could definitely see where a lot of people could get the idea that carbs=good, fats=bad.
  • About glucose, some carbs do metabolize to fructose.
  • Fructose metabolizing like ethanol and causing liver dysfunction is still pretty controversial in the mainstream nutrition community, right?
  • Alcohol's not controversial.
  • And of course starving to death is bad.

Calories-wise, in my own diet:

  • I avoid sugars (including basically any fruit sweeter than a tomato or red bell pepper) like the plague. And yes that's because I think they're terrible for you. But also, I have violent acute symptoms when I imbibe, which... is kinda good thing to some extent. I've got a feedback mechanism. I don't know whether it's glucose, fructose, or sucrose that gives me symptoms, but I avoid all of those. I don't think things like dextrose or artificial sweeteners (which of course don't have calories, but anyway) would give me the acute symptoms, but I don't eat any of those either.
  • Carbs are a sometimes thing. Usually they take the form of white rice, sweet potatoes, or russet potatoes. (Because those metabolize only to glucose and I have a history of NASH.) I do high carbs no more than once a week.
  • The meats I eat are mostly sardines, pork, and chicken, but I don't really avoid beef. Neither do I avoid the fattier cuts of meat or anything.
  • I eat eggs quite a lot.
  • I do eat a fair amount of olive oil, but seed oils aren't anything I'd eat except extremely rarely. And I don't avoid butter.
  • Of course, fuck trans fats. And I've never drunk alcohol.
[-] jet@hackertalks.com 2 points 6 hours ago

Fructose metabolizing like ethanol and causing liver dysfunction is still pretty controversial in the mainstream nutrition community, right?

I've seen no controversy here, the metabolic pathway is the same, its mechanical and observable. There are people saying whole fruits are a net-benefit in-spite of this. But I haven't seen any serious advocate pushing for high fructose corn syrup as a health food.

I have violent acute symptoms when I imbibe, which… is kinda good thing to some extent. I’ve got a feedback mechanism

It's nice to have feedback!

[-] alyqz@lemmy.sdf.org 3 points 1 day ago

I think this study is just saying that extremes are bad and you should eat a balanced diet.

[-] jet@hackertalks.com 1 points 1 day ago

I found it really interesting they found a dose dependent relationship in carbohydrate percentages ranging from 60%-80%. It's very suggestive that maybe the relationship extends even below 60%

this post was submitted on 02 Oct 2025
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