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3,000 Long-COVID sufferers learn about new nicotine patch therapy
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Tl;dr: Recommended dosage for people without prior nicotine use is 7 or 7.5mg per day, apparently. However, in another study, two patients administered 15mg per day and also got very good results (but with some transient side-effects).
In the study in question, they first give a case report on page 13:
There is also this similar paper from 2023 by the same authors. In the section "Methods", they likewise report giving their patients dosages of 7.5mg per day. As they explain, they choose this low dosage because their patients were all "nicotine-naive", which I understand as a hint that in cases of (former) smokers, they might give a higher dosage.
Of one patient (41-year-old male, Case 3), they write that he mistakenly administered a higher dosage of 15mg/day, which he had to cease after 10 hours because of nausea. Yet, despite this (or maybe because of this?), this patient experienced a far-reaching recovery from the Long Covid symptoms over the following days.
Of another patient (52-year old male, Case 4), they write:
Further up, somewhere in the introduction, they write something which makes it seem like that higher doses of nicotine are in principle safe and well-tolerated up until quite a large dosage, at least for patients with different diseases. (The mileage of Long Covid or ME/CFS sufferers could of course vary heavily here.):
Spoiler
These are all relevant occurrences of "mg" in these two papers.
Of note, all their patients administered the full dosage immediately from the first hour.
Thanks, I think I will try again with a higher dosage.