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PSA: Don't take 4 packets of paracetamol in one day
(lemmy.dbzer0.com)
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I think the reason is that both acetaminophen and opioids are processed by the liver and that acetaminophen will overwhelm it allowing more time for opioids to be effective.
You can take acetaminophen and nsaids together because they work differently and are processed differently.
But, if you're a heavy drinker, both are dangerous for very different reasons. Liver vs digestive tract.