As already commented, the vast majority of apps are fine with Graphene and its optional sandboxed Play Services. Mainly some banking apps can be tricky, but otherwise you're good. You can also use alternatives like Aurora Store rather than Google directly to get your existing apps which aren't on F-Droid; the only real exception there is paid ones.

I got a Pixel and made the switch over about a year ago, and it has been pretty smooth sailing. I also really do appreciate having full control over which permissions to allow each app. I know some people do prefer to run Google's stock camera app or keyboard, but it's easy enough to not give those network access to phone home.