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this post was submitted on 01 Sep 2024
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TechTakes
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Big brain tech dude got yet another clueless take over at HackerNews etc? Here's the place to vent. Orange site, VC foolishness, all welcome.
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i suspect - i don't know, but suspect - that it's really leveraging all known protein structures ingested by google and it's cribbing bits from what is known, like alphafold does to a degree. i'm not sure how similar are these proteins to something else, or if known interacting proteins have been sequences and/or have had their xrds taken, or if there are many antibodies with known sequences that alphaproteo can crib from, but some of these target proteins have these. actual biologist would have to weigh in. i understand that they make up to 96 candidate proteins, then they test it, but most of the time less and sometimes down to a few, which suggests there are some constraints. (yes this counts as one iteration, they're just taking low tens to 96 shots at it.) is google running out of compute? also, they're using real life xrd structures of target proteins, which means that 1. they're not using alphafold to get these initial target structures, and 2. this is a mildly serious limitation for any new target. and yeah if you're wondering there are antibodies against that one failed target, and more than one, and not only just as research tools but as approved pharmaceuticals