A quick note on "Abilities and autos have ~50% chance of not going through": this is because the timers are desync'd due to the speedup. If you're trying to use an ability immediately after the client thinks it's come off cooldown, it's actually still on cooldown. You can verify by pinging your ability right as it comes off cooldown to see when it actually comes back up. For example if I'm spamming Q on Alistar, when the client says it's off cooldown, it still has ~2s left before coming up. Higher CD abilities will have a bigger discrepancy.
This post is like 2 different issues I've been having combined into one. Since gnome 44 (on arch, so 44.1, 44.2, and 44.3 so far; didn't have this issue on gnome 43), if I'm on wayland, I can't load into a game without it being invisible in the background, with no window I can see. The wine virtual desktop alleviates this issue, but I opted to switch back to X11 until this is fixed.
On X11, my game sometimes fails to transition from champ select to loading screen. A fullscreen window pops up for a fraction of a second and disappears, followed by the client coming back up with the "reconnect" button. The first couple games where this happened, I was able to launch the game after ~3-5 reconnect attempts, and the game played like normal. Lately however, it will continue crashing no matter how many times I reconnect. The only way for me to launch into the game is to completely stop league (kill it via lutris) and relaunch, and that's what appears to trigger the game to be a desynchronized mess, as the OP described. One silver lining is that it sometimes fixes itself mid-game after a while.
I'm also on lutris-ge-lol-8.7-1, with an RX 6700XT fwiw.
I'll try out the gstreamer file fix mentioned by @auracon (I have the same error messages in my lutris logs, but they also appear without the desync bug) and if that doesn't work, I'll try switching to the wine virtual desktop
A quick note on "Abilities and autos have ~50% chance of not going through": this is because the timers are desync'd due to the speedup. If you're trying to use an ability immediately after the client thinks it's come off cooldown, it's actually still on cooldown. You can verify by pinging your ability right as it comes off cooldown to see when it actually comes back up. For example if I'm spamming Q on Alistar, when the client says it's off cooldown, it still has ~2s left before coming up. Higher CD abilities will have a bigger discrepancy.
This post is like 2 different issues I've been having combined into one. Since gnome 44 (on arch, so 44.1, 44.2, and 44.3 so far; didn't have this issue on gnome 43), if I'm on wayland, I can't load into a game without it being invisible in the background, with no window I can see. The wine virtual desktop alleviates this issue, but I opted to switch back to X11 until this is fixed.
On X11, my game sometimes fails to transition from champ select to loading screen. A fullscreen window pops up for a fraction of a second and disappears, followed by the client coming back up with the "reconnect" button. The first couple games where this happened, I was able to launch the game after ~3-5 reconnect attempts, and the game played like normal. Lately however, it will continue crashing no matter how many times I reconnect. The only way for me to launch into the game is to completely stop league (kill it via lutris) and relaunch, and that's what appears to trigger the game to be a desynchronized mess, as the OP described. One silver lining is that it sometimes fixes itself mid-game after a while.
I'm also on lutris-ge-lol-8.7-1, with an RX 6700XT fwiw.
I'll try out the gstreamer file fix mentioned by @auracon (I have the same error messages in my lutris logs, but they also appear without the desync bug) and if that doesn't work, I'll try switching to the wine virtual desktop