I think the wonkiest dice I've ever played with for this would be Eclipse Phase. It's a "d100 under skill" system, but uses the number you rolled as degree of success. So it's like blackjack; rolling high is better, as long as you don't bust. That difficulty modifier can turn a roll from amazing to awful. It's not bad, and it's never caused confusion, it's just funny.

I'm re-learning Champions and transition from 1st/2nd edition from my childhood to 6e. It's definitely tricky to get used to the whole system, but I love it. roll 3d6 +11 + OCV - DCV tells you DCV that you can hit...you want to roll low, not high to hit. Or just straight 3d6 for Skill and Ability checks and roll under a certain number. The only thing you want to roll high on is damage. 10d6 damage? That's pretty common! There's a whole diffferent science to it, but I'm really enjoying wrapping my head around it as a change from 5e.

Tried TDE once, that resolution system is awful.