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submitted 10 months ago by MicroWave@lemmy.world to c/health@lemmy.world

A Welsh scientist working on a new male pill wants to reduce the burden on women of protecting against unwanted pregnancies.

Prof Chris Barratt is leading research on a non-hormonal drug which prevents sperm cells from reaching an egg.

His team at the University of Dundee has received significant funding from the Bill and Melina Gates Foundation.

"It's been a very poorly researched topic for 40 or 50 years," Prof Barratt said, but society has changed.

His team's research could see men given a gel or a pill that would affect the sperm cell, effectively disabling its function.

Instead of targeting the production of sperm, his research focuses on slowing the sperm cells' swimming action down and making them similar to those in infertile patients.

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[-] iiGxC@slrpnk.net 33 points 10 months ago
[-] Scubus@sh.itjust.works 23 points 10 months ago

Adding to this: as a mid-20s person, I was always told that I would not be able to get a vasectomy without certain stipulations, like already having children. That really pisses me off, since that defeats the entire point.

I recently talked to my doctor though, and they stated that that is not the case(for men, women evidently don't get to control their bodies). So for anyone else trying to get one, make sure to talk to your doctor. They may be able to hook you up.

[-] iiGxC@slrpnk.net 5 points 10 months ago

Yeah I got mine no problem, but I found the urologist on the r/childfree wiki's list of doctors. Fuck reddit, but it is a good resource, and they have doctors for vasectomies and hysterectomies

[-] Maximilious@kbin.social 4 points 10 months ago

Vasectomy's are reversible while tube tieing is not. It's still bullshit females can't make that decision for themselves though.

[-] NOPper@lemmy.world 16 points 10 months ago

Technically reversible, but in no way guaranteed.

However, if you can afford to freeze some sperm there's that option.

[-] stufkes@lemmy.world 8 points 10 months ago

My gynecologist said I must be at least 35 and have a child for the procedure to be considered...

[-] stepan@lemmy.world 7 points 10 months ago

Vasectomies are meant to be permanent. Even if you get your vasectomy reversed, your fertility may never come back. Vasectomy reversal surgery is complicated and expensive, and doesn’t always work. So you should only get a vasectomy if you’re totally certain you don’t want to get someone pregnant for the rest of your life." - Planned Parenthood

Literally a five second google search will debunk your own point

[-] rickyrigatoni@lemm.ee 2 points 10 months ago

I think this is one of those things that depends where you are. I've heard of guys trying to get vasectomies in the deep south getting the run around because they didn't have kids.

[-] CADmonkey@lemmy.world 1 points 10 months ago

This is what I experienced in Oklahoma.

[-] CADmonkey@lemmy.world 5 points 10 months ago

Almost a year since I had mine done, my wife and I both enjoy it.

[-] iiGxC@slrpnk.net 3 points 10 months ago
[-] FatAdama@programming.dev 4 points 10 months ago

It wasn’t that bad. And I’m glad I did it. No more kids.

[-] stevedidWHAT@lemmy.world 20 points 10 months ago

I’ll take the ball bath over fucking with my hormones any day of the week. I saw what they did to women

[-] otter@lemmy.ca 13 points 10 months ago* (last edited 10 months ago)

I saw what they did to women

Part of it is that women are currently using it and taking on all of the risks/consequences from it. Some couples would like the ability to transfer the risk to the other partner (different couples will have different reasons for their choice).

Another thing to note is that regulatory agencies are more strict now than back when there was a focus on birth control for women. Like that thing with alcohol would be banned if it was "invented" today. If a male pill IS approved, it would likely be a lot safer than what women are taking now.

Idk about this specific trial, I'm speaking generally

[-] Tessellecta@feddit.nl 8 points 10 months ago* (last edited 10 months ago)

It's not really that the regulators have become more strict. Most of the female birth control options would likely be approved today. The issue with male birth control is more the way they assess whether a medication is 'worth it' to take.

For women the risk and side effects of birth control are weighted against being pregnant. Since being pregnant is really dangerous, the side effects can be more severe. For example, hormonal bc causes a slight risk of a stroke, however being pregnant causes this risk to go up more. Therefore the risk of the bc is acceptable.

For men there is no such medical benefit to bc, therefore it must have very very little to no side effects to be approved.

[-] stepan@lemmy.world 1 points 10 months ago

So it has to do with threshold and relative risk/loss analysis?

[-] stevedidWHAT@lemmy.world 3 points 10 months ago

I share sentiments with tessellecta - not so sure we looked at all the features when comparing apples to oranges

[-] DessertStorms@kbin.social 13 points 10 months ago

There have been several attempts at this over the years and at the final hurdle they always fail because men refuse to deal with any of the side effects (but are happy for us to continue to do so), and/or with the toxic idea of it being "emasculating".

And if it ever did get past those hurdles, it might work for couples in a long term trusting relationship, but I, nor any other woman I know, would trust some random guy to have either taken the pill and/or be honest about it. If "stealthing" is a thing, believe that people would lie about taking a pill. Even if it had to be taken on the spot, some people would come up with ways to fake it. I'm not going to risk it, and I'm in the UK where we still have semi-reasonable access to abortion, I can't imagine anyone with more restricted access being willing to..

[-] BritishDuffer@lemmy.world 16 points 10 months ago

You have absolutely no idea if the side effects are comparable between male and female birth control pills. Nobody does. Maybe stop to consider the that side effects might be really bad, before just invalidating the experience of all those who have tested it?

[-] DessertStorms@kbin.social 6 points 10 months ago* (last edited 10 months ago)

Lmmfao, typical.. You having absolutely no idea, doesn't mean I don't, since I actually read the reports I'm talking about when they came out years ago, and the side effects were essentially identical to those women have been expected to put up with for decades.

You can pretend toxic masculinity and male fragility and entitlement, never mind the male dominance and minimisation of women's suffering in medicine, don't exist all you like, but that doesn't make them any less real or impactful.. ¯\(ツ)

[-] BritishDuffer@lemmy.world 11 points 10 months ago* (last edited 10 months ago)

You're not actually that slow, are you? Just because the side effects have the same names doesn't mean they're in any way comparable. If you actually read any of the trial reports you'd know the side effects they described were crippling.

Hormonal pills have horrible side effects for some women, but for millions of women around the world the benefits well outweigh the side effects. If you did any of this reading you claimed to do you'd know that wasn't the case with the male trials at all.

[-] girl@lemm.ee 2 points 10 months ago* (last edited 10 months ago)

That info is pretty easy to find. The side effects included acne, mood swings, mood disorders, and suicidal thoughts. They’re the same symptoms that women’s birth control causes. Women also face weight gain and a risk of blood clots.

Source

Source 2

[-] Salad_Fries@lemmy.world 10 points 10 months ago* (last edited 10 months ago)

From my understanding, its more along the lines of “risk averse regulators see the side effects as unacceptable”… not “crybaby men are crybabies” like your post infers. (Seriously, your post has some really toxic vibes)

Birth control has a lot of very horrible side effects.. in addition to the common hormonal changes, they also come with things such as an increased risk of stroke.

For women, child birth is extremely intense on the body with lots of increased risk. Lets look at the stroke side effect as an example.. birth control causes increased risk of stroke, but pregnancy causes an even higher risk of stroke. Its easy for regulators to justify the stroke risk of birth control because it actively prevents the higher stroke risk of pregnancy.

For men, child birth comes with no risk whatsoever because they cant physically get pregnant. lets look at that same stroke side effect for example.. birth control provides increased risk of stroke, but comes with no medical benefit. that increased risk is extremely difficult to medically justify.

Essentially, childbirth/pregnancy is extremely high risk for women, which makes it easier to justify the side effects for a medication that prevents it. The risks of childbirth/pregnancy dont exist for men though, so its much harder to justify the same side effects.

Yes, it feels unfair and fucked up, but thats because reproduction is inherently unfair and fucked up…

there may be something to be said about whether or not the regulators factor in the externalities of the pregnant partner when looking at approving such medication.. i have absolutely no clue though.

[-] DessertStorms@kbin.social 2 points 10 months ago* (last edited 10 months ago)

Oh please, do mansplain to me about the risks of pregnancy some more, I hadn't had a fucking clue! 🙄🙄🙄

You assholes just can't fucking help yourselves, can you??? 😂

It's not as if there are other ways to stop pregnancy if the risk is such a concern, if only men didn't regularly refuse them too, perhaps women wouldn't have to suffer the hormonal hell men have_ the privilege_ to refuse, that is imposed on us often from puberty on top of that risk. But clearly it isn't really that much of a concern after all.. Not for men.

Also, because I'm not wasting any more energy on you:

You can pretend toxic masculinity and male fragility and entitlement, never mind the male dominance and minimisation of women's suffering in medicine, don't exist all you like, but that doesn't make them any less real or impactful.. ¯(ツ)/¯

[-] Salad_Fries@lemmy.world 7 points 10 months ago

Oh please, your toxic incel-like worldview effectively proved my point. pregnancy is inherently unfair and fucked up.. the unfair nature of it makes the burden of risk inherently unfair & fucked up.

No amount of male birth control is going to make you content, so i ask, what the fuck are you advocating for?

[-] stepan@lemmy.world 4 points 10 months ago

Yeah. I think you explained it well. The bodies themselves are different, so it makes sense why the interventions are different.

We could use male condoms, but the problem is couples don't like that because they want as much of the sexual process to continue naturally.

If you want the process to go uninterfered as much as possible, it makes sense to put the cork at the end of the race (right before fertilization).

If you're ok with interfering at the beginning, by all means use a male condom (put the cork at the start of the race).

[-] DarkroomDoc@lemmy.world 7 points 10 months ago

This is belied by the fact that one of the most common elective procedures for men is a vasectomy. It (actually) has more to do with numbers. In men you have to block millions of sperm- in women it’s one egg. Physiologically, it’s an easier problem to solve in women.

[-] stepan@lemmy.world 5 points 10 months ago* (last edited 4 months ago)
  1. male BC requires stopping essentially thousands of sperm, while female BC only requires stopping one egg from attaching. That's why female BC is physiologically "simpler".

  2. risk is relative. For example, woman's BC risk is weighed against childbirth, because childbirth is dangerous. That's why women's BC has a relative advantage. Childbirth isn't something that men face, which is why men's BC has no relative advantage. That's why the bar for BC is strict with men. It's because the situations are different.

  3. (related to point #2) trust and liability. If the man lies about taking BC, the woman ends up pregnant. The risk and responsibility lie on the woman.

  4. the reason why the BC responsibility typically falls on the woman has to do more so with the nature of our bodies and how far people want the sexual process to travel.

For example, we could just make it so that every man wear a condom during sex. But there are both men and women who don't like that, because they want to "feel a more natural sex". Condoms interrupt the natural process right at the start. What's ideal is that as much of the process happens normally, and it is only stopped at the end to prevent fertilization. Following that logic, the sperm travels towards the egg and you wanna stop it right then before the end (for example, a cervical cap perhaps).

Women are on the receiving end of the sexual process, so if the couple doesn't want a condom, or if they want the sex to feel as natural as possible, logic follows that the "stopper-plug" would be in the woman, because the finish line of fertilization takes place inside a woman.

If the couple is ok with a stopper plug closer to the beginning of the race, just use a condom then.

I'll address your comment now.

Your first paragraph honestly comes off as quite toxic and bitter now that I'm reading it again. Everybody has bodily autonomy and the right to refuse anything, and the reason is irrelevant. You have 3 choices.

  1. The woman accepts the BC,

  2. the man accepts the BC, or

  3. both refuse and just decide that you can't have sex.

You don't want female BC that's fine. Nobody here is shaming you for your choice. If you don't want it that's fine. But the same standard applies to the men you're choosing to date. If they don't want it, that's the end of that conversation. Move on to option 3. What you don't have is the right to scold or shame your partner because they don't wanna take something they aren't comfortable with. You should accept option 3 if the first two aren't available.

[-] optissima@lemmy.ml 1 points 10 months ago

Your first paragraph honestly comes off as quite toxic and bitter now that I'm reading it again. Everybody has bodily autonomy and the right to refuse anything, and the reason is irrelevant.

Most women don't have bodily autonomy, why are you claiming otherwise?

[-] stepan@lemmy.world 3 points 10 months ago

Allow me to rephrase it then.

Everybody should have the right to refuse any sort of intervention.

Somebody offers you a medication or procedure and is like "here try this" you should be able to say "no thanks, I don't want it"

And that's the end of that.

[-] olafurp@lemmy.world 2 points 10 months ago

I for one would have liked to get one in my twenties and skipped out on some of the worries.

You may be remembering the study from almost 10 years ago where a whole bunch of men got injections and some stopped because they got severe acne. Now, that seems like a wimp thing to do. It doesn't include the fact that some men had wild mood swings with it (doesn't happen with womens pill), one developed severe depression, and one successfully committed suicide.

I also disagree with the wording from NPR - men didn't "complain" about the side effects, they REPORTED them. Because they were on a clinical study. And that's what you do on clinical studies.

The boards overseeing the trial stopped it at that point. The men that stayed in on the trial would have kept going if they could have, even with the side effects. So no - men can and have dealt with the side effects.

"stealthing" is also a thing now. It's just women claiming to be on the pill to men instead of vice versa. Trust between two people always has to be there, and some people will break that trust to get their parts licked. It's human nature, not a man vs woman vs NB thing.

Stealthing still going to be a problem with STIs, even with a pill/injection male contraception. Condoms are still going to be necessary.

[-] RobotToaster@mander.xyz 11 points 10 months ago

I'm not sure if this is the same one I read about before (YCT529) the article doesn't seem to mention it be name. If it is I would be very wary of side effects, being a retinoic acid receptor antagonist it's basically doing the opposite of tretinoin.

[-] MicroWave@lemmy.world 10 points 10 months ago

Looks like this one is not YCT-529, which is being developed by YourChoice and the University of Minnesota College of Pharmacy.

https://www.pharmacy.umn.edu/news/yourchoice-therapeutics-begins-first-human-trial-male-birth-control-pill

this post was submitted on 31 Dec 2023
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