Podcast Interview with Jay Shetty ("On Purpose") - In her final major interview, Panettiere made several damning allegations. She revealed she was sex trafficked at age 18 by a trusted friend who led her to a yacht, where she was put into a room with a naked, "very famous" man. She also alleged that a famous British rocker, around 30 at the time, attempted to sexually assault her on a boat. Additionally, she claimed that Neutrogena invoked a morality clause in her contract to try and fire her after she spoke publicly about her postpartum depression in 2015.

Interview with Tamron Hall (May 2026) - While promoting her memoir This Is Me: A Reckoning, Panettiere discussed her determination to "reset her life". She recounted being given "happy pills" by a trusted adult at age 16 before walking a red carpet and revealed that a doctor told her she would need a liver transplant by age 35 if she didn't stop drinking.

Entertainment Weekly Interview (September 2025) - In a career-spanning interview, Panettiere reflected on her work and her daughter's pride in her. She spoke about the emotional toll of playing characters, like on Nashville, whose struggles with postpartum depression mirrored her own real-life battles.

People Magazine Interview (September 2024) - This interview went viral due to Panettiere's appearance. Viewers expressed concern about her slurred speech and tired look. She later explained that she had been awake for two days caring for her sick dog. In the interview, she spoke emotionally about the death of her brother, Jansen.

Interview with "Extra" (2024) - Panettiere opened up about the severe impact of postpartum depression, saying it "really kicked in" and that she was "crying on set, like, all the time" while working.

Interview about "Nashville" Trauma (2024) - She spoke out about the "profound distress" she experienced on the set of Nashville, revealing that the show's writers often drew heavily from her real-life experiences, including her dating life and struggles with alcoholism, with little alteration.

Interview Regarding Abuse by a Famous Hollywood Figure (2026) - In addition to the incidents on the yacht, Panettiere revealed that at age 19, she was harassed by a well-known, Oscar-winning actor and director. This was part of a broader denunciation of the industry's failure to protect young women.

Statement on the "Live with Kelly and Michael" Incident (2026) - In multiple interviews promoting her book, she detailed the fallout from her 2015 appearance. She stated that after discussing her postpartum depression, she received a call that Neutrogena wanted to fire her, and that she heard nothing from the company, not even a "great working with you for 10 years".

Interview Regarding Domestic Abuse (2026) - A resurfaced interview from May 2026 with TMZ featured her on-off boyfriend, Brian Hickerson, who was convicted of domestic abuse, candidly discussing the abuse he inflicted on her.

Interview Regarding Child Stardom and "Paving the Way" (2025) - In her interview with EW, Panettiere stated she was proud of her career and her ability to "pave the way for people out there who are experiencing some of the things that I have gone through personally", framing her life experiences as a means to help others.