This and then the new about regrowing teeth. Its a very exciting time in medicine.
If you think anyone but the elite will be able to afford or procure these procedures, you're incredibly optimistic.
As soon as it gets approved, some shitty corporation will purchase the patent and lock it behind a paywall for 80+ year old geriatrics with zero fucks given towards people who actually deserve or need it.
So… anywhere but the USA it will be affordable(ie free) anyways? Okay.
Bremonia will have the procedures, for free. The name can be changed, I don't care. I just need help overthrowing a few corrupt governments and I'm out.
This drug can be delivered via pill. It has a range of effects in reversing age related damage.
I'm not sure if it will be kept to the rich, or given out widely to justify the removal of social security, or at least jacking up the retirement age.
Maybe, but if PGE2 signaling is disrupted in non-cartilage tissues, it could promote abnormal growth or inflammation. For example, PGE2 has complex roles in cancer and fibrosis. And if the drug isn’t perfectly specific, it might inhibit other enzymes or pathways. This is because 15-PGDH is active in other tissues (e.g., liver, muscle, bone). Inhibiting it systemically might affect these tissues, though the study suggests localized joint injection could minimize this I suppose...
“Everything sucks.”
Boring.
Probably worth adding "in mice" to the title
Mice are really living in a golden age. They have never been so healthy.
The only downside is the never ending genocide at the hands of scientists
And human tissues, and it's been shown to be safe in phase I trials.
So saying "in mice" undersells where they are at.
Ready for someone to tell me why this unfortunately won't work / become mainstream
Money, usually. Or cancer. God i sound depressing 😄
Money cancer.
Ah, the billionaires again.
Well, this same drug (working name MF-300) is a PDGH-15 inhibitor and has already been through phase 1 human trials for a separate condition.
Because PDGH-15 also causes age related muscle weakness.
Now, PDGH-15 also plays a role in cancer prevention, and there may be a few other less obvious functions.
I don't know if the results of the phase 1 trials have been published yet, but it's been a while since I checked.
I've been hearing about MF-300 for a little under a year, and with these same claims about restoring cartilage.
Good. Biological aging is nothing more than a series of processes, not an inherent property of atoms, and it's time we start getting serious about anti-aging and life extension.
But probably not, seeing what the world is like.
Its mostly billionaires who will be able to benefit from life extension... do you really want a world where trump, musk, and all their silicon valley friends rule the world until they turn 300 years old?
Luckily there's no vaccine against guillotines.
Give it time.
Aroooooo
Americans, we get it, you have no healthcare system worth the name. Stop assuming nobody else worldwide can get the meds either.
Exactly. Functional public health systems will assess patient outcomes and the expenditure in money and resources to determine what treatments get approved.
The odds are pretty good that - if this works out - this will be on the list of approved treatments straight away. Surgery is an expensive and high-load pathway for public health systems. A non-surgical treatment that gives good outcomes is such a win-win for both patients and public health systems that it almost doesn't matter how much it costs.
I want this so bad, I have lost all cartilage in my wrists and I don't want to get them fused.
I couldn't imagine how shitty that must be, I really hope this advancement does help you regrow yours so you don't have to get them fused.
I would like to order one new left knee cartilage please!
Finally some good fucking news.
When they compared cartilage from young and old mice, they found that levels of 15-PGDH approximately doubled with age. To test the idea, researchers treated older mice with a small molecule drug that blocks 15-PGDH activity. [And cartilage regrew.]
Sounds very promising! I couldn't figure out the peer-reviewed-ness status.
I’m in this thumbnail and I want that right now.
Wow, this is really exciting. I guess it’ll take years more research before we’ll know if this can benefit humans, but if they can replicate the results with humans then it could potentially prevent chronic pain and mobility issues in millions of people.
Hopefully not just humans. Many dogs for example suffer from the very same issues when they get older.
This is just epic news. Well done all the scientists for making this happen. :)
Just in time for me to get old!
This is a most excellent place for technology news and articles.
