This is really interesting. As I was reading the article I was wondering how they were going to wring money out of it, as amlodipine is off patent. Then I got to this part:

“While amlodipine shows promise in preclinical models, it is not currently suitable for use in ADHD in its marketed form,” Karlsson noted. “Further optimization through chemical modification is necessary to enhance CNS selectivity and ensure a favorable therapeutic index in the context of ADHD.”

Classic big pharma. Slightly tweak an existing drug in an insignificant way so that you can get a new patent on it and charge exorbitant prices.

common blood pressure drugs are already used to treat ADHD and in my experience they're pretty fucking bad at it compared to stimulants.

So uh, what if I already take this for blood pressure. Am I getting a double whammy?

I had a doctor try to force me off my atenolol and metoprolol to amlodipine. Ostensibly because she "didn't like" that I was taking such a high dose of two separate beta-blocker meds. Not sure if she thought I was going to take them all in a fit of despair, or what, but it went really badly. My anxiety and ADHD were a lot worse, rather than better, and my BP skyrocketed.

I can't take stimulants. My body can't metabolize them well (or at all?), so I end up knocked unconscious for half the day. Basically, 6-8 hours where I can stay awake only by fighting tooth and nail. Even on fractional doses! Wild stuff. While their results are interesting (especially for those like me who failed every single non-stimulant, hard) this could be helpful. Oooor it could just be more big pharma BS with no up-side. So hard to tell anymore.

I've taken Amlodipine in the past, and while it was effective at controlling blood pressure it basically turned me into a zombie. I didn't feel like doing anything while taking it. I don't see how that could help with ADHD.