It's been said already in this thread, but I'll echo my experience too.
At first I was leaning into the sense of urgency and tried to play immersively. I was managing my resources, planning ahead, limiting short rests and conserving spell slots, often taking on fights with my whole team already bloodied.
Mechanically, this was very enjoyable to me, both the sense of pressing on through straining circumstances and the added challenge and resource management.
As others have said, though, BG3 anchors an absolute TON of story and companion events to Long Rests, and I consequently missed out on an incredible amount of content, some of which seem to have permanently locked me out of progressing certain companion relationships, as well as missing out on the owlbear cub joining the camp and probably a lot more too.
I really wish there was a day/night cycle that would naturally force you to set up camp frequently in a more natural fashion, but as it is I recommend to basically take Long Rests as often as possible, especially in Act 1.