I'm curious, is SKSE even supported through proton? Not sure why it wouldn't but still curious.
I never got Skyrim with mods running through wine or proton, never found a good way to untangle the mess of Steam, Skyrim, Mod Organiser 2.
That's why Skyrim is one of the last games running in dual boot Windows
I'm not sure completely so someone will have to chime in with the specifics but I remember watching a streamer that played modded on Linux and I'm pretty sure that he ran mo2 through steam for the proton compatibility so that when he launched skse in mo2 it would launch under proton.
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