Mega Karen has special abilities that the other Karen's don't.
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Speed Dial Manager: an ability to store and recall store manager phone numbers from Mega Karen's cell phone.
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Family Minions: husband and children will back up Mega Karen even though she's in the wrong. On special occasions Mom/sister/cousin can be activated.
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Double-Down: Mega Karen will insist and try even harder when cornered.
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Extra HP: Mega Karen does not mind wasting more time than other lesser powered Karen's.
Though Mega Karen is hard to defeat she still uses a predictable pattern. She always moves in to recording you on her phone. You'll know she's started running low on HP when she starts getting hysterical and becomes the "victim". If fought right, the battle usually ends with Mega Karen being escorted off the battle field but sometimes she can be knocked out. Sadly she gives very little Skill Points when she's defeated and it's due to her Low IQ and Value to the world.