467
Methamphetamines
(lemmy.world)
I like that the sign says "will" kill you, not "could".
If it said “could”, most people would think “probably not me, though”.
Exactly.
Local anesthetics with vasoconstrictors should be used with care in patients taking methamphetamine because they may result in cardiac dysrhythmias, myocardial infarction, and cerebrovascular accident.
Dang.
For some reason "cerebrovascular accident" sounds so funny to me, it's like "uh oh, seems like my brainy-veiny did an oopsie-whoopsie".
We don't make mistakes, we just have happy accidents
A minor infarction.
What about aderall and vyvanse?
I had to be put under with local anaesthesia for a septoplasty and they said I couldn't take Vyvanse. I wasn't going to anyway, it increases your blood pressure. But still good that they tell you.
I’m happy the other person hasn’t had issues, but my dentist called me to let me know they couldn’t put me under because of my prescription… which is Adderall and Vyvanse.
May have just been the Adderall, maybe it was both, but I don’t like going under anyway and was going to use local anesthesia, regardless.
Adderall and Vyvanse are essentially the same drug. You're on both?
Yup. Adderall alone was too much, Vyvanse alone was too little. A max dosage of one and a smidge if the other during the middle of the day if needed?
Just right.
Edit: to go with what the other person said - my metabolism is really fast and I typically run “hot.”
Interesting approach. I myself use a non -stimulant (atomoxetine) daily with a supplement of Adderall as needed
They are related drugs with similar profiles, but they are not the same drug. Vyvanse is Lisdexamfetamine, which is a pro-drug, that your body converts into dextroamphetamine. This can have a big impact on some people, either making the drugs more or less tolerable. Actual metabolic rates for drugs can be significantly different from person to person.
Yes, but Adderall is dextroamphetamine, the drug Vyvanse turns into.
I'm familiar with the pharmacology and their respective mechanisms, just stating that they're essentially the same drug
They are not the same drug, reread what I said. You can't be very familiar with pharmacology if you don't understand prodrugs. They turn into almost Adderall, which isn't straight dextroamphetamine. This changes how they effect the body, you can say "essentially the same" all you want, but it's not true when it comes to how they actually impact people. Differing metabolic rates due to naturally different levels of metabolizing enzymes causes prodrugs to have more variance in their peak blood serum levels, it causes later onset of effect and can cause large variance in duration of effect. This can be very helpful or even dangerous for some people. They are not perfectly interchangeable, even if most people find them pretty similar.
Unrelated comment: I'm interested in following this exchange, but it's collapsed, dunno if the pic embeds here or what. I click, jerboa crashes, rinse and repeat. I dunno, just felt like talking about. Dunno if anyone else has had similar dysfunction.
I'm on Connect not having a problem.
I'm just using Lemmy on Firefox mobile. Jerboa became too unstable for me and this so far has worked the best imo.
Try liftoff.
Thank you. Adderall (amphetamine + dextroamphetamine) gave me intolerable side-effects at the minimum effective dose for me. That's my doctor moved me to dextroamphetamine, which has been lovely. They are not the same.
I had the same thought. I always disclose my meds first, but if you're taking them but not prescribed I'd still tell them.
Kill You with a capital "K"
Good thing I only use Ice
We call it “ice” in Australia 😝 random trivia
(and China)
There was a girl in my sixth grade class named Yaba and I never thought "well she looks like a tall pile of crystal meth"
I wonder about other amphetamines. Because there's some things you can take turn into amphetamines when your body processes them, IIRC. There are also medications that are in the same family. I suspect that while people do usually tell their dentist what medications they're taking when prompted, some people are kind of flaky and forget, while other people might have a reason in their head not to. But, not everybody thinks to disclose stuff like "supplements" which are unregulated, variably legal, and could also pose a health risk if they qualify for this particular scenario. Good of them to tell people that though. I never knew that and I've gotten lots of dental work done, although, I've never done hard drugs.
I know this isn't what you meant, but I choose to read this as you calling meth a "supplement"
It's a nootropic, bro
Hell, they still prescribe meth in some instances. It's called Desoxyn. Adderall, a drug so commonly used right now there's a shortage (or was, very recently), is a strong amphetamine. They're used for a quite a lot medically, and all have similar effects on the body by definition.
The issue at play here is amphetamines are doing a number on vasoconstriction and heart contractility, which then boosts heart rate and BP. This increases the chance of all that fun stuff like ischemic/hemorrhagic stroke, heart attack, or a dangerous dysrhythmia. When you add in anesthesia that has similar effects (vasoconstriction), you massively increase the odds of a complication. Thats without considering the already existing damage likely present in those abusing drugs of this sort.
Not a lot of people realise that the lidocaine you get at the dentists also contains epinephrine to make it last long. Which can play merry hell with your blood pressure. I can't have epinephrine for other medical reasons besides the way it messes with your blood pressure and honestly I prefer it, I'm numb long enough to do the surgery and it's all gone in half an hour or so instead of a numb face for half the day.
Lidocaine and epi are an interesting combo. There is a lot of literature on where and when they can be used in conjunction and where they absolutely cannot be used together. Anesthesia is a very complex subject and super intriguing.
I always mention vitamins and stuff, just in case. No matter what, I will not lie to my doctor in any situation, it's one of my rules of life
Your username is way more interesting than the post lmao
Wow, I guess you know what part of the city you're in when you have that appointment with this dentist.
It's a fairly standard thing for dentists to advertise, at least where I am. I've been to multiple dentists that had similar signs or very prominent warnings on the paperwork you sign in the waiting room. These were all suburban dentists.
Wow! I have been absent from the United States for a long time (I'm assuming this is from the USA, where I'm from). What a thing! I had no idea this was typical back home. I guess it's a good thing. I mean, it prevents death, right?
Prescribed medications in the same class have the same side effect.
Ah! I get it, then. I guess I was reading this poster as a kind of warning to recreational drug users because I didn't put my pharmacology hat on. Thanks for the clarification. The more I interact with people on this thread, the more I see how it makes sense to post warnings like this.
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this post was submitted on 30 Jul 2023
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