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this post was submitted on 29 May 2024
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The pancreas is not really stable enough to be implanted in at all. Other organs you're imagining like liver, stomach, heart, etc. have a solid lining that can be cut open and stitched back together. The pancreas is more like a cluster of loose cells with veins throughout and held together by a very thin, tissue paper lining. If you try to open it and insert cells, you're not going to be able to put it back together.
That's why cells are usually put in the liver, which has a large vein going directly to the pancreas. Close proximity and high blood supply. Implanting in the pancreas will likely never be an option unless you can drastically reduce the volume of cells.
Our lab was working on implanting the stem cells on a porous scaffold in the fat pad of the stomach as an alternative