Absolutely. I have been using tablet PCs since 2011, all of which have run desktop operating systems. My first was an ASUS that ran Windows 7, which I used for school and later for TTRPG. OneNote was excellent software which got me through that phase of my life.

I later upgraded to a laptop-type tablet instead of a slate with a Bluetooth keyboard. I find the format more convenient. The Yoga has been excellent for me — though I don't like the keyboard a lot as I'm used to the chunkier type. The pen has a battery so I do have to pause to charge it after a few hours of writing/drawing, but that has been nice because it forces me to take breaks (which can be hard when you have ADHD!) The pen is a bit narrow and now super ergonomic, but there are many compatible styluses out there that are larger.

As for software, I've switched to Linux as of many years ago and up until recently there were not many good apps out there for handwritten notes. Xournal++ is ugly but good for marking up PDFs. Rnote is a very new app, written in Rust and designed around GNOME design principles, so it looks very nice and is quite fast. It's not a 1:1 replacement for OneNote — it has basic file management but not as advanced as OneNote's notebooks and tabs and pages, and there is no OCR for searching within your handwriting. I would not use it to do worldbuilding, but it has been more than good enough for me to take rough notes as I play.

The downside of the Yoga is that it has soldered RAM, so you need to get one with good enough specs right off the bat. I purchased a 16GB model and it has been sufficient, though the processor is a downgrade from my last laptop. I still use my desktop for beefier jobs. One example of where it struggles is that when I played 5e with a group, if I rolled digital dice on DND Beyond the performance was quite slow. This seemed to be an issue for everyone on a laptop, though.