It could be done as a series of vignettes, for example, as 6 episode series, with each series centred around each crisis. That would give you 4-5 hours - or 2.5 Mrs Doubtfires - to do what Asimov does in around 60 pages (depending on crisis).

I don't understand the argument that this is impossible to do, pretty much every film you will have ever seen will have had a shorter runtime than 5 hours, and handled all aspects of character introduction, motivation, conflict, growth, and resolution, within than time too.

I am not saying it has to be identical or a word for word adaptation - I have no issues what so ever with gender swapping Hardin - but as another poster points out, having Seldon live on (other than as recordings getting increasingly divorced from reality) directly rejects the core premise of the book, which is a refutation of the great man hypothesis.