One of my favorites was a Defect deck which used seeks, double energy, and a dark orb to one shot Deca & Donu on turn one. Hearing the orb go off like 60 times was incredible.
Posting it here for visibility
https://youtu.be/-n_yfNgdHCE?si=b0C62O2odKweTycS
A place to discuss Slay the Spire the video game
Posting it here for visibility
https://youtu.be/-n_yfNgdHCE?si=b0C62O2odKweTycS