Yes, although like someone else mentioned - I don't, and ever wouldn't try to host it at home, but on a server at a data center. The network is operated by a person I know and trust.

No IP reputation issues that I've run into, but even going in I knew that its very rare I send emails so it probably wasn't going to be an issue either way. I've only had it running for about two years now, but in that time frame I've sent one email out where I "started the conversation", and three emails where I was replying back to someone who already had my email in their address book.