Most of what I see as 'issues' are personal preferences. Stuff like railroaded dialog choices even worse than Fallout 4, or stiff/awkward voice acting, or landing on planets being randomly generated despite claims otherwise. But as for actual issues, two things stood out to me: spaceship flight is very dangerous because bumping into things has a good chance of bugging the physics engine and killing you instantly (but other times, barely even registering damage). And seeing a player get stuck because they got a bounty without even knowing it, and then the bounty was making them shoot-on-sight by guards and them having no clue how to deal with the bounty. I'm sure there's a perfectly simple way out of the situation, but without any communication to the player, that's nothing but frustration. Add in broken NPC pathing/animations (people getting stuck inside objects like bar counters), making it all-too-easy to fall down ladder holes in ships, and horrible performance optimization (with Todd Howard being quoted telling people to just buy better computers), and I think it'll need a bit of polish before really considering giving it a shot.