I've never used FL but I've seen people mention they're had success with it on Linux.

This guide looks legit.

https://linuxvox.com/blog/flstudio-linux/

When I first started with audio production it was with Audacity. When I realized it wasn't the best way to record an album I switched to Ardour. It was compared to Pro Tools a lot at the time and I don't know how similar they are but I loved using it. When I started working with some new people I switched to their preferred DAW, Reaper. Now I basically only use Reaper because it's easier for some of the people newer to production. Ardour is still amazing and I think you should try them both and see which you like more. Maybe you can get FL working well but I think it's better to use something that runs native so you can support the orgs that are producing software for Linux and so eliminate some headaches.

I use native plugins as much as possible but sometimes a collaborator will use something meant for Windows and Mac only. What I do is install the plugin with WINE, using default paths, de-selecting any bullshit I don't care for, and then run a command to sync the plugins, yabridgectl sync. Sometimes plugins don't work perfectly because of missing fonts or whatever but there's a lot of advice on the project page for individual plugins. I've had pretty good luck so far but currently there's a rendering issue I'm waiting for an update on. Mouse clicks are offset for some reason. It's probably fixed by now in the stable version. It's been a month or two since I've checked on it since there are plenty of native and built-in plugins within Reaper.

https://github.com/robbert-vdh/yabridge