The trick is to murder the youngest bees, and by bees I mean children.

Then, you can use retaliatory airstrikes as an excuse to kill more children. Destroy their industrial infrastructure - agriculture, energy, transport, sewage - and turn their cities (I mean hives) into charnel pits. Use misinformation and armed groups of political opponents to kick off a civil war. Demolish schools, hospitals, mosques, and critical businesses to deprive citizens of a safe place to congregate. Then send in special forces to assassinate anyone successful at organizing numbers of people to resist.

Eventually, you'll kill off all the peop- uh- bees. The human insects. I guess you can call them Bug People.