Advanced whatever will always lead to philosophy, and there are no definitive answers there or elsewhere. You can debate the meaning of a state of matter, of gender, of life, of number, etc. (That's why there is philosophy of physics, biology, mathematics, chemistry...). So I don't think that's the point.

Yes, both sex and gender get complex, but the answer to conservatism isn't to say that advanced science has it all figured out because that would be a lie. They'll ask us to demonstrate ontological categories that we cannot demostrate through science. It might be true sometimes the: "you are conservative because you rely on basic science, and progressivism and other leftists ideas lie on advanced science", but ultimately, the debate is open and we need to be careful not to bluff about science being on our side because science has its limits.

Philosophy is the final battleground, and in there we do have strong arguments, but still, I feel this "smarter than thou" attitude is not it.