There's a lot more to it than that.

There was widespread feeling that if they just went along with it, the Nazis would leave them alone. That was a deadly wrong assumption. There's also factors like having enough able-bodied young adults to do it when there was a need for them to take care of older people.

Forgotten Weapons has a video about a college paper he wrote on the topic. It largely shows that people in the Jewish Ghettos could get crude but workable firearms if they needed, but the factors above tended to get in the way.

As were some of the groups in the Civil Rights movement. There was a group armed and trained by a black WW2 veteran that protected families from retaliation by the KKK for going to desegregated schools. Armed with rifles and machine guns, they would put sandbag emplacements on people's porches to ensure that their kids were safe throughout the night.

Together, monkey strong. When we're divided, it's much easier to silence us one by one. And that doesn't even need guns to be involved in the equation.

Harder, not impossible.

The ones that fought back often had a higher survivability rate than those that did not. Especially those that survived the ghetto uprisings to join resistance groups such as the Bielski Brothers. So while nothing was guaranteed, armed resistance did increase the odds of survival.