Nothing that matters to the Naruto storyline, no. Filler episodes don't impact the overall story, just some character focus bits about who they are.

You can always just read the summary for those episodes too.

What I would say among the fillers worth watching are:

• Naruto 101 is fantastic and could be considered canon with what happens later on in the story.
• Shippuden 349-361 is the kakashi back story. Its right in the middle of great story, but IMO worth watching. You could even watch this between Naruto and Shippuden.
• Shippuden 484-500 is adapted from official novels, so some call it filler, others call it canon. I'd recommend it.

Thats about it though. The rest are more of an "if you feel like it".