ARM has bit-banding specifically for this. I think it’s limited to M-profile CPUs (e.g. v7-M) but I’ve definitely used this before. It basically creates a 4-byte virtual address for every bit in a region. So the CPU itself can’t “address” a bit but it can access an address backed by only 1 bit of SRAM or registers (this is also useful to atomically access certain bits in registers without needing to use SW atomics).

Tell this to the LPC1114 I'm working with. Did you ever run a multilingual GUI from 2kbytes RAM on a 256x32 pixel display?