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$16bn health agency managed finances with Excel spreadsheet.
(www.theregister.com)
This is a most excellent place for technology news and articles.
Interesting, never thought about using python as an excel replacement. Definitely wouldn't work in my current work setting. But I just started taking a python class and I'll have to keep this in mind.
Once you get the basics of Python, you need to learn the Pandas library. Also, check out Jupyter notebooks right now, is going to make your life easier.