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Why most countries are struggling to shut down 2G.
(restofworld.org)
This is a most excellent place for technology news and articles.
So is the difference between 2g, 3g, 4g and 5g that they use different channels/frequencies, different communication protocols, or both?
Both, really. There's been encoding improvements every generation, but they also use different slices of the spectrum.
There's also changing from circuit to packet switching, which also drastically changes how the handover process works.
tl;Dr - handover in 5G is buggy and barely works. The whole thing of switching from one service area to another in the middle of a call is held together by hopes and dreams.
Both of those, and also different signal modulation.