You can easily do a same-day wire transfer of this amount. Technically there's no limit on the size of wire transfers. There's probably a point where the bank will start asking questions, but car / mortgage down-payment sized transfers aren't an issue.

But, yeah, I bet cash withdrawals are another ballgame. Not least because the bank probably doesn't actually keep that much cash in typical customer-facing locations.

Is there not a security concern of doing basic checks before handing out cash?

For instance, elderly woman gets a text message telling her the IRS needs $50k cash or they’ll take her house. The bank says they need a few days, she complains that the IRS wants it now…and then they help explain that it’s likely a scam.